| Type | Description |
|---|---|
| Definition | protein phosphatase, Mg2+/Mn2+ dependent 1B |
| Date | Results | Publications |
|---|---|---|
| 2020-10-10 12:57:00 | TRIM59 promotes tumor growth in hepatocellular carcinoma and regulates the cell cycle by degradation of protein phosphatase 1B. | 31875525 |
| 2018-10-27 10:44:00 | Results indicate that protein phosphatase 1B (PPM1B) negatively regulates cancer cell motility and invasiveness through dephosphorylating Rho guanine nucleotide dissociation inhibitor 1 (RhoGDI1). | 29307615 |
| 2018-09-22 11:47:00 | PPM1B plays a negative role in the activation of the p38-RB1-E2F1 pathway and that targeting PPM1B could be useful in certain types of cancer by stimulating chemotherapy-induced cell death. | 29654756 |
| 2017-02-04 12:30:00 | This study has identified PPM1B and miR-186 as potential diagnostic markers in bladder cancer. Promotion of PPM1B and suppression of miR-186 may offer effective therapeutic strategies in the treatment of bladder cancer. | 26494000 |
| 2015-05-30 12:14:00 | PPM1B interacts with Groucho 4 and is localized to DNA in a Groucho-dependent manner, and phosphatase activity is required for transcriptional silencing. | 25631048 |
| Type | IDs |
|---|---|
| Synonymous | PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX |
| Gene |
UniProtKB-ID:
PPM1B_HUMAN
UniprotKB:
O75688
UniParc:
UPI000002B03B,
UPI0000552B0A,
UPI000006FDC4,
UPI0000130FE7,
UPI0000552B09
EMBL:
AL833035,
DQ023510,
AJ005801,
AJ271832,
AC019129,
CH471053,
DQ023508,
BC064381,
DQ023509,
AJ271835,
AF136972,
BC012002,
AC013717,
AF294792
Ensembl:
ENSG00000138032
KO:
hsa:5495
|
| Nucleutide sequences |
EMBL-CDS:
CAC27992.1,
AAY89639.1,
AAH64381.1,
AAG49433.1,
EAX00282.1,
AAX88954.1,
CAA06704.1,
AAY89640.1,
CAH56319.1,
AAH12002.1,
EAX00283.1,
CAC27993.1,
AAY89641.1,
AAG02232.1
Ensembl_TRS:
ENST00000345249,
ENST00000282412,
ENST00000378551,
ENST00000409432
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000387287,
ENSP00000282412,
ENSP00000326089,
ENSP00000367813
RefSeq:
NP_002697.1,
NP_808907.1,
NP_001028729.1,
XP_016859886.1,
XP_011531238.1,
XP_016859885.1,
NP_808908.1,
XP_016859884.1
|
| Others |
UniRef100:
UniRef100_O75688
UniRef90:
UniRef90_O75688
UniRef50:
UniRef50_O75688
UniGene:
Hs.416769
CCDS:
CCDS1816.1,
CCDS1818.1,
CCDS46271.1,
CCDS1817.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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