| Type | Description |
|---|---|
| Definition | MMS22 like, DNA repair protein |
| Date | Results | Publications |
|---|---|---|
| 2019-01-05 10:53:00 | uncovered DNA-PKcs-dependent DNA damage-induced ASF1A phosphorylation, which enhances chromatin assembly, promoting MMS22L-TONSL recruitment and, hence, Rad51 loading. | 29478807 |
| 2017-07-08 12:08:00 | By specifically regulating RAD51 activity at uncoupled replication forks, MMS22L-TONSL stabilizes perturbed replication forks by promoting replication fork reversal and stimulating their homologous recombination-mediated restart in vivo. | 27797818 |
| 2016-07-30 11:52:00 | new histones incorporated during DNA replication provide a signature of post-replicative chromatin, read by the human TONSL-MMS22L homologous recombination complex | 27338793 |
| 2014-01-04 11:34:00 | Our data strongly suggest that targeting MMS22L as well as its interaction with NFKBIL2 could be a promising strategy for novel cancer treatments. | 22895565 |
| 2011-01-15 11:16:00 | Results strongly suggest that the Mms22L-Nfkbil2 complex contributes to genome stability by regulating the chromatin state at stalled replication forks. | 21113133 |
| Type | IDs |
|---|---|
| Synonymous | C6orf167, dJ39B17.2 |
| Gene |
UniProtKB-ID:
MMS22_HUMAN
UniprotKB:
Q6ZRQ5
UniParc:
UPI00003673C9
EMBL:
CH471051,
AK128060,
AL023656,
AL353679,
CR749603,
AL590484,
CR749822
Ensembl:
ENSG00000146263
KO:
hsa:253714
|
| Nucleutide sequences |
EMBL-CDS:
EAW48494.1,
CAH18682.1,
CAH18398.1,
EAW48496.1,
BAC87254.1
Ensembl_TRS:
ENST00000275053
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000275053
RefSeq:
XP_011533974.1,
XP_011533980.1,
XP_011533982.1,
XP_011533976.1,
XP_011533981.1,
XP_011533977.1,
XP_011533972.1,
XP_011533973.1,
XP_011533978.1,
NP_001337528.1,
XP_006715495.1,
XP_016866145.1,
NP_001337529.1,
XP_011533979.1,
NP_940870.2
|
| Others |
UniRef100:
UniRef100_Q6ZRQ5
UniRef90:
UniRef90_Q6ZRQ5
UniRef50:
UniRef50_Q6ZRQ5
UniGene:
Hs.444292
CCDS:
CCDS5039.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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