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645 BLVRB

645

BLVRB

biliverdin reductase B

protein-coding

Homo sapiens

基因描述

Type Description
Definition biliverdin reductase B

研究结论

Date Results Publications
2021-02-13 13:29:00 Structure, dynamics and function of the evolutionarily changing biliverdin reductase B family. 32246827
2019-01-12 11:56:00 Early stages of lineage fate potential require glutamine anaplerotic functions and an intact Pentose phosphate pathway, which are, in part, regulated by BLVRB activity. In principle, BLVRB inhibition represents an alternative strategy for modulating cellular glutamine utilization with consequences for cancer and hematopoietic metabolism. 29500232
2018-12-22 10:15:00 These results provide promising chemical scaffolds for the development of enhanced BLVRB inhibitors and identify chemical probes to better dissect the role of biliverdins, alternative substrates, and BLVRB function in physiologically relevant cellular contexts. 29487133
2017-08-05 11:15:00 These data define the first physiologically relevant function of BLVRB and implicate its activity and/or heme-regulated BV tetrapyrrole(s) in a unique redox-regulated bioenergetic pathway. 27207795
2016-08-13 10:23:00 miR-127-5p suppressed NF-kappaB activity by directly targeting BLVRB in hepatocellular carcinoma cells. 26708147

名称对应

Type IDs
Synonymous BVRB, FLR, HEL-S-10, SDR43U1
Gene
UniProtKB-ID: BLVRB_HUMAN, V9HWI1_HUMAN
UniprotKB: P30043, V9HWI1
UniParc: UPI0000111B1A
EMBL: BC109371, AC010271, D26308, AK312137, D32143, CH471126, AY340485, EU794593
Ensembl: ENSG00000090013
KO: hsa:645
Nucleutide sequences
EMBL-CDS: AAP88933.1, AAI09372.1, BAA06874.1, EAW56969.1, BAG35073.1, BAA05370.1, ACJ13647.1
Ensembl_TRS: ENST00000263368
Protein sequencees
Ensembl_PRO: ENSP00000263368
RefSeq: NP_000704.1
Others
UniRef100: UniRef100_P30043
UniRef90: UniRef90_P30043
UniRef50: UniRef50_P30043
UniGene: Hs.515785
CCDS: CCDS33029.1

全选

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