| Type | Description |
|---|---|
| Definition | PDS5 cohesin associated factor A |
| Date | Results | Publications |
|---|---|---|
| 2020-09-12 16:02:00 | PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection. | 31757807 |
| 2019-08-24 11:49:00 | depletion of Rad21 in a Pds5-deficient background rescues the phenotype observed upon Pds5 depletion alone. These findings support a model where loss of either component of the cohesin releasin complex perturbs cohesin dynamics on replication forks, hindering fork progression and promoting MRE11-dependent fork slowing | 29917110 |
| 2017-12-30 10:51:00 | The results show that cohesin has an essential genome-wide function in mediating long-range chromatin interactions and support the hypothesis that cohesin creates these by loop extrusion, until it is delayed by CTCF in a manner dependent on PDS5 proteins, or until it is released from DNA by WAPL. | 29217591 |
| 2017-12-02 10:21:00 | These results provide the first evidence indicating a tumor suppressor role of SA1 in early colon carcinogenesis | 27549371 |
| 2016-04-09 11:35:00 | By interacting with a unique domain of Esco1, Pds5 recruits Esco1 to chromatin-bound cohesin complexes to form cohesion. | 26051894 |
| Type | IDs |
|---|---|
| Synonymous | PIG54, SCC-112, SCC112 |
| Gene |
UniProtKB-ID:
PDS5A_HUMAN,
G1UI16_HUMAN
UniprotKB:
Q29RF7,
G1UI16
UniParc:
UPI00006C6A7E,
UPI000000D9A5
EMBL:
AK098331,
CH471069,
AB621803,
BC126225,
BC041361,
AF294791,
AB014548,
BC114218,
CR749425,
AY550968
Ensembl:
ENSG00000121892
KO:
hsa:23244
|
| Nucleutide sequences |
EMBL-CDS:
BAA31623.1,
BAC05286.1,
AAT52214.1,
AAM82347.1,
AAH41361.1,
CAH18263.1,
AAI14219.1,
AAI26226.1,
EAW92953.1,
BAK64139.1
Gene_ORFName:
PIG54,
hCG_38551
Ensembl_TRS:
ENST00000503396,
ENST00000303538
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000303427,
ENSP00000426749
RefSeq:
XP_016863417.1,
NP_001093870.1,
NP_001093869.1,
XP_011511974.1
|
| Others |
UniRef100:
UniRef100_Q29RF7
UniRef90:
UniRef90_Q29RF7
UniRef50:
UniRef50_Q29RF7
UniGene:
Hs.331431
CCDS:
CCDS54759.1,
CCDS47045.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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