| Type | Description |
|---|---|
| Definition | VPS18 core subunit of CORVET and HOPS complexes |
| Date | Results | Publications |
|---|---|---|
| 2019-06-15 11:02:00 | Study characterized the ubiquitinomes of Vps11/18 and demonstrated that these two factors are involved in the regulation of signal transduction by protein ubiquitination. VPS11/18 regulate several signaling factors and pathways, including Wnt, estrogen receptor alpha (ERalpha), and NFkappaB. | 31015428 |
| 2017-10-28 11:24:00 | VPS18 recruits VPS41 to the human HOPS complex via a RING-RING interaction | 28931724 |
| 2011-07-16 11:30:00 | Depletion of hVps18 or hMon2 reduced the efficient production of infectious HIV-1 virions in human cells. | 21450827 |
| 2010-01-21 00:00:00 | hVPS18 may play an important role in regulation of SNK activity through its ubiquitin ligase | 16203730 |
| 2010-01-21 00:00:00 | ubiquitin binding and ubiquitylation of GGA3-GAT domain are mutually inseparable through a ubiquitin ligase activity of hVPS18 | 16996030 |
| Type | IDs |
|---|---|
| Synonymous | PEP3 |
| Gene |
UniProtKB-ID:
VPS18_HUMAN,
A0A024R9R3_HUMAN
UniprotKB:
Q9P253,
A0A024R9R3
UniParc:
UPI0000049FBC
EMBL:
CH471125,
BC001513,
AB040908,
AF308802,
AL713725
Ensembl:
ENSG00000104142
KO:
hsa:57617
|
| Nucleutide sequences |
EMBL-CDS:
AAG34679.1,
BAA95999.1,
CAD28515.1,
AAH01513.1,
EAW92464.1,
EAW92465.1
Gene_ORFName:
hCG_38959
Ensembl_TRS:
ENST00000220509
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000220509
RefSeq:
XP_011520146.1,
XP_011520145.1,
NP_065908.1,
XP_016877936.1
|
| Others |
UniRef100:
UniRef100_Q9P253
UniRef90:
UniRef90_Q9P253
UniRef50:
UniRef50_Q9P253
UniGene:
Hs.23876
CCDS:
CCDS10069.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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