| Type | Description |
|---|---|
| Definition | isocitrate dehydrogenase 3 (NAD(+)) alpha |
| Date | Results | Publications |
|---|---|---|
| 2020-04-11 12:38:00 | IDH3alpha is elevated in glioblastoma patient samples compared to normal brain tissue and promotes glioblastoma progression in orthotopic glioma mouse models. On molecular levels, IDH3alpha ablation reduces TCA cycle turnover and shunts energy metabolism. In addition, IDH3alpha affects one-carbon metabolism and regulates nucleotide production as well as DNA methylation through effect on cSHMT. | 30613765 |
| 2020-03-14 11:44:00 | This study highlights the importance of including this rarely-mutated gene in the molecular diagnostic set-ups for inherited retinal degenerations, and further delineates the phenotypic spectrum elicited by mutations in IDH3A. | 31012789 |
| 2015-11-28 10:42:00 | The silencing of IDH3a significantly delayed tumor growth by suppressing the HIF-1-mediated Warburg effect and angiogenesis. | 25531325 |
| 2010-12-05 22:08:00 | Observational study of gene-disease association. (HuGE Navigator) | 20877624 |
| 2010-04-07 21:40:00 | Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | 20306291 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
IDH3A_HUMAN,
B7Z9J8_HUMAN
UniprotKB:
P50213,
B7Z9J8
UniParc:
UPI0000E02258,
UPI000012D1AC,
UPI0000072C97
EMBL:
AK315963,
CH471136,
AL442090,
U07681,
AK316051,
BC021967
Ensembl:
ENSG00000166411
KO:
hsa:3419
|
| Nucleutide sequences |
EMBL-CDS:
EAW99181.1,
AAH21967.1,
EAW99182.1,
AAA85639.1,
CAC09449.1,
BAH14334.1,
BAH14422.1
Ensembl_TRS:
ENST00000299518
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000299518
RefSeq:
XP_005254393.1,
NP_005521.1,
XP_024305679.1,
XP_024305680.1
|
| Others |
UniRef100:
UniRef100_P50213
UniRef90:
UniRef90_P50213
UniRef50:
UniRef50_P50213
UniGene:
Hs.591110
CCDS:
CCDS10297.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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