| Type | Description |
|---|---|
| Definition | methionine adenosyltransferase 1A |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 12:59:00 | Structural basis of the dominant inheritance of hypermethioninemia associated with the Arg264His mutation in the MAT1A gene. | 32496220 |
| 2020-06-27 11:53:00 | Three newborns were identified with MAT I/III deficiency by newborn screening were found to carry MAT1A gene variants including two missense variants [c.776C>T (p.Ala259Val) and c.791G>A (p.Arg264His)] and a synonymous variant [c.360C>T (p.Cys120Cys)] | 32335878 |
| 2020-02-22 11:39:00 | Overexpression of MAT1A in 5637 bladder cancer cells increased tolerance to gemcitabine and stalled cell proliferation rates, suggesting MAT1A upregulation as a potential mechanism by which bladder cancer cells persist in a quiescent state to evade chemotherapy. | 31600961 |
| 2019-04-27 10:07:00 | The simultaneous downregulation of MAT1A and upregulation of MAT2A are necessary and sufficient for hepatocellular carcinoma metastasis in the process of M1-M2 switch. | 29749642 |
| 2018-06-30 11:32:00 | Increased MAT1A expression is associated with recurrence in hepatocellular carcinoma. | 29448301 |
| Type | IDs |
|---|---|
| Synonymous | MAT, MATA1, SAMS, SAMS1 |
| Gene |
UniProtKB-ID:
METK1_HUMAN
UniprotKB:
Q00266
UniParc:
UPI000012EFF3
EMBL:
D49357,
X69078,
CH471142,
AL359195,
BC018359
Ensembl:
ENSG00000151224
KO:
hsa:4143
|
| Nucleutide sequences |
EMBL-CDS:
AAH18359.1,
BAA08355.1,
EAW80396.1,
EAW80397.1,
CAA48822.1
Ensembl_TRS:
ENST00000372213
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000361287
RefSeq:
NP_000420.1
|
| Others |
UniRef100:
UniRef100_Q00266
UniRef90:
UniRef90_Q00266
UniRef50:
UniRef50_P13444
UniGene:
Hs.282670
CCDS:
CCDS7365.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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