| Type | Description |
|---|---|
| Definition | BCL2 associated athanogene 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:30:00 | The Small Nuclear Ribonucleoprotein Polypeptide A (SNRPA) binds to the G-quadruplex of the BAG-1 5'UTR. | 32629040 |
| 2020-05-09 11:20:00 | Bag-1 is overexpressed in breast tumors in all molecular subtypes. Bag-1 forms complexes with B-Raf, C-Raf and Akt in breast cancer cells, enhancing their phosphorylation and activation, and ultimately leading to phosphorylation of the pro-apoptotic Bad protein at Ser112 and Ser136. This causes Bad's re-localization to the nucleus, and inhibits apoptosis in favor of cell survival. | 31883527 |
| 2019-12-14 12:04:00 | We demonstrated a critical role for the rG4 in the control of both cap-dependent and independent translation of the BAG-1 mRNA in colorectal cancer cells. Additionally, we found an upstream ORF that also represses BAG-1 mRNA translation | 31504805 |
| 2019-07-20 13:01:00 | Study in human osteosarcoma line U2OS expressing a conditional MYC-ER allele revealed that small isoform of BAG1, BAG1S, in cooperation with the HSP70 chaperone complex, selectively mediates cell survival in MYC overexpressing tumor cells and identified a set of specific pro-survival clients controlled by the HSP70/BAG1S chaperone complex. | 30902071 |
| 2019-07-13 11:51:00 | Bag-1 targeted therapy might enhance the therapeutic potential of conventional anti-cancer drugs in the treatment of breast cancer. | 30661182 |
| Type | IDs |
|---|---|
| Synonymous | BAG-1, HAP, RAP46 |
| Gene |
UniProtKB-ID:
BAG1_HUMAN
UniprotKB:
Q99933
UniParc:
UPI0001D1472B,
UPI0000F0A52C,
UPI0001BBBBE7,
UPI0000000C39
EMBL:
AF116273,
CH471071,
AL356472,
BC014774,
AF022224,
Z35491,
AL161445,
AK222749,
U46917,
BC001936
Ensembl:
ENSG00000107262
KO:
hsa:573
|
| Nucleutide sequences |
EMBL-CDS:
EAW58514.1,
AAD25045.1,
AAC34258.1,
AAD11467.1,
AAH01936.2,
CAA84624.1,
AAH14774.2,
EAW58515.1,
BAD96469.1
Ensembl_TRS:
ENST00000379704
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000369026
RefSeq:
NP_001336215.1,
NP_004314.6,
NP_001165886.1,
NP_001336228.1
|
| Others |
UniRef100:
UniRef100_Q99933
UniRef90:
UniRef90_Q99933
UniRef50:
UniRef50_Q99933
UniGene:
Hs.377484
CCDS:
CCDS35004.1,
CCDS55301.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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