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3728 JUP

3728

JUP

junction plakoglobin

protein-coding

Homo sapiens

基因描述

Type Description
Definition junction plakoglobin

研究结论

Date Results Publications
2021-02-13 13:25:00 Plakoglobin is involved in cytoskeletal rearrangement of podocytes under the regulation of UCH-L1. 32560811
2020-03-07 12:16:00 FLG and DST support melanoma cell growth in vitro and in vivo. Growth effects of JUP were only evident in vivo, and may be mediated, in part, by enhancing angiogenesis. In addition, growth-promoting effects of FLG and DST in vitro suggest that these genes may also support melanoma cell proliferation through angiogenesis-independent pathways. 31425296
2020-02-08 11:16:00 gamma-catenin signaling is involved in the initiation and maintenance of BCR-ABL1(+) B-cell acute lymphoblastic leukemia. 30991025
2020-02-01 11:40:00 revealed that JUP was overexpressed in oral squamous cell carcinoma (OSCC), and that JUP promoted the proliferation, migration, and invasion of OSCC cells and inhibited apoptosis 31420988
2019-05-25 10:57:00 Ectopic expression of HDAC7 suppresses mRNA and protein levels of plakoglobin in lung cancer cells, whereas silencing HDAC7 increases the the expression of plakoglobin. Overexpression of plakoglobin significantly reduces the enhanced cell proliferation, migration and invasion induced by ectopic HDAC7. HDAC7 suppresses plakoglobin by directly binding to its promoter. 30628670

名称对应

Type IDs
Synonymous CTNNG, DP3, DPIII, PDGB, PKGB
Gene
UniProtKB-ID: PLAK_HUMAN, A0A0S2Z487_HUMAN
UniprotKB: P14923, A0A0S2Z487
UniParc: UPI0000073ED4
EMBL: AF233882, AF306723, BC000441, M23410, KU178155, Z68228, CH471152, BC011865, AY243535, AC109319, AJ249711
Ensembl: ENSG00000173801
KO: hsa:3728
Nucleutide sequences
EMBL-CDS: AAH11865.1, AAG16727.1, EAW60762.1, AAH00441.2, AAA64895.1, CAA92522.1, CAC04246.1, AAO85780.1, ALQ33613.1
Ensembl_TRS: ENST00000310706, ENST00000393931, ENST00000393930
Protein sequencees
Ensembl_PRO: ENSP00000311113, ENSP00000377507, ENSP00000377508
RefSeq: XP_016880077.1, XP_006721938.1, XP_011523058.1, NP_068831.1, NP_001339702.1, NP_001339704.1, XP_006721937.1, NP_001339703.1, XP_011523055.1, XP_016880079.1, NP_001339706.1, XP_011523060.1, NP_002221.1, NP_001339705.1
Others
UniRef100: UniRef100_P14923
UniRef90: UniRef90_P14923
UniRef50: UniRef50_P14923
UniGene: Hs.514174
CCDS: CCDS11407.1

全选

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