| Type | Description |
|---|---|
| Definition | anaphase promoting complex subunit 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-04 10:05:00 | Fibroblast studies showed that the intronic mutation causes the activation of a 95 bp pseudoexon, leading to mRNAs with premature termination codons and nonsense-mediated decay, decreased ANAPC1 protein levels, and prolongation of interphase | 31303264 |
| 2020-01-04 12:05:00 | The anaphase promoting complex/cyclosome (APC/C) E3 ligase is not simply an interaction hub, but a dynamic, multifunctional molecular machine whose structure is remodeled by binding partners to achieve temporal ubiquitylation regulating cell division [Review]. | 30482618 |
| 2019-04-06 12:26:00 | Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density. | 30894546 |
| 2018-03-03 12:05:00 | Data show that FZR1 (Fzr), a cofactor of the multi-subunit E3 ligase complex anaphase-promoting complex/cyclosome (APC/C), represents a therapeutic target in myeloma. | 27655696 |
| 2018-03-03 11:19:00 | in the Alzheimer's disease (AD)mouse model APP/PS1, lower cdh1 levels were observed in pyramidal neurons in CA1 when compared to age-matched wildtype mice. In this review, we provide a complete list of APC/C substrates that are involved in the nervous system and we discuss their functions. We also summarize recent studies that show neurobiological effects in cdh1 knockout mouse models. | 28505105 |
| Type | IDs |
|---|---|
| Synonymous | APC1, MCPR, TSG24 |
| Gene |
UniProtKB-ID:
APC1_HUMAN
UniprotKB:
Q9H1A4
UniParc:
UPI000006EC6E
EMBL:
AK023807,
BC005089,
AJ278357,
BC104904,
BC104902
Ensembl:
ENSG00000153107
KO:
hsa:64682
|
| Nucleutide sequences |
EMBL-CDS:
AAI04903.1,
CAC19484.1,
BAB14687.1,
AAH05089.1,
AAI04905.1
Ensembl_TRS:
ENST00000341068
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000339109
RefSeq:
XP_016860199.1,
XP_016860202.1,
XP_016860204.1,
XP_016860203.1,
XP_016860200.1,
XP_011509935.1,
XP_016860201.1,
NP_073153.1,
XP_011509936.1
|
| Others |
UniRef100:
UniRef100_Q9H1A4
UniRef90:
UniRef90_Q9H1A4
UniRef50:
UniRef50_Q9H1A4
UniGene:
Hs.436527
CCDS:
CCDS2093.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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