| Type | Description |
|---|---|
| Definition | mediator complex subunit 12 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:33:00 | CYP24A1 expression analysis in uterine leiomyoma regarding MED12 mutation profile. | 33025089 |
| 2021-02-27 13:45:00 | Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance. | 32752274 |
| 2020-10-31 13:19:00 | MED12 exon 2 mutation is uncommon in intravenous leiomyomatosis: clinicopathologic features and molecular study. | 32240666 |
| 2020-05-30 13:24:00 | The N-terminal portion of MED12 wraps around CDK8, whereby it positions an "activation helix" close to the T-loop of CDK8 for its activation. | 31988137 |
| 2020-05-09 12:33:00 | Study demonstrates that while MED12-CDK8 binding is altered in leiomyoma tissue samples the observed change is not consistent with a global loss of CDK8 recruitment that would result from exon 2 mutation-dependent MED12-cyclin C-CDK8 interaction defect. Modified enhancer architecture is a major driver of transcriptional dysregulation in MED12 mutant uterine leiomyomas. | 32094355 |
| Type | IDs |
|---|---|
| Synonymous | ARC240, CAGH45, FGS1, HOPA, MED12S, OHDOX, OKS, OPA1, TNRC11, TRAP230 |
| Gene |
UniProtKB-ID:
MED12_HUMAN
UniprotKB:
Q93074
UniParc:
UPI000021230F,
UPI0000212306,
UPI00004257E2
EMBL:
U80742,
AF132033,
D83783,
AF071309,
AF117755,
AL590764
Ensembl:
ENSG00000184634
KO:
hsa:9968
|
| Nucleutide sequences |
EMBL-CDS:
BAA12112.1,
AAC83163.1,
AAD44162.1,
AAB91440.1,
AAD22033.1
Ensembl_TRS:
ENST00000374102,
ENST00000374080
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000363215,
ENSP00000363193
RefSeq:
NP_005111.2
|
| Others |
UniRef100:
UniRef100_Q93074
UniRef90:
UniRef90_Q93074
UniRef50:
UniRef50_Q93074
UniGene:
Hs.409226
CCDS:
CCDS43970.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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