| Type | Description |
|---|---|
| Definition | protein phosphatase 6 regulatory subunit 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-04 10:30:00 | The substitution of Ala in nine putative phosphorylation sites in SAPS3 was required to prevent CK2 activation of the phosphatase. Different CK2 chemical inhibitors equally increased phosphorylation of endogenous AURKA in living cells, consistent with reduction in PP6 activity. | 31904830 |
| 2018-07-23 13:17:00 | Results from a study on gene expression variability markers in early-stage human embryos shows that PPP6R3 is a putative expression variability marker for the 3-day, 8-cell embryo stage. | 26288249 |
| 2018-05-19 11:36:00 | we found a DPP9-PPP6R3 fusion transcript in one tumor showing a matching genomic 11;19-translocation. Another tumor had a rearrangement of DPP9 with PLIN3. Both rearrangements were associated with diminished expression of the 3' end of DPP9 corresponding to the breakpoints identified by RNA-seq. | 28893231 |
| 2017-07-08 12:57:00 | Molecular analyses revealed the presence and amplification of the novel PPPR6-USP6 gene fusion, which resulted in USP6 mRNA transcriptional upregulation. These findings further support the oncogenic role of the USP6 protease in mesenchymal neoplasia and expand the biologic potential of Nodular fasciitis | 27113271 |
| Type | IDs |
|---|---|
| Synonymous | C11orf23, PP6R3, SAP190, SAPL, SAPLa, SAPS3 |
| Gene |
UniProtKB-ID:
PP6R3_HUMAN,
H7BXH2_HUMAN,
A0A024R5F3_HUMAN
UniprotKB:
Q5H9R7,
H7BXH2,
A0A024R5F3
UniParc:
UPI00001FADF3,
UPI00001FADFD,
UPI0000039F2E,
UPI00004DCAE7,
UPI0000228F28,
UPI0000688150,
UPI0000039F2C
EMBL:
BC107599,
AB046778,
CR749815,
AP003096,
AF264779,
CR933658,
AK057250,
BC105933,
BC105934,
CH471076,
AP001788,
DQ111954,
AF264780,
AL834471,
AK001920,
AP000807,
BC007738
Ensembl:
ENSG00000110075
KO:
hsa:55291
|
| Nucleutide sequences |
EMBL-CDS:
BAB13384.2,
AAZ99639.2,
AAI05935.1,
AAI05934.1,
CAD39130.1,
BAA91978.1,
BAB71396.1,
AAI07600.1,
AAG36935.1,
CAI45957.1,
AAH07738.2,
CAH18675.1,
AAG36934.1,
EAW74709.1,
EAW74712.1,
EAW74711.1
Gene_ORFName:
hCG_26461
Ensembl_TRS:
ENST00000524845,
ENST00000393801,
ENST00000524904,
ENST00000393800,
ENST00000265636,
ENST00000529710,
ENST00000265637
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000377389,
ENSP00000437329,
ENSP00000431415,
ENSP00000265636,
ENSP00000377390,
ENSP00000433058,
ENSP00000265637
RefSeq:
XP_006718677.1,
NP_001339284.1,
XP_024304371.1,
XP_016873466.1,
NP_001339282.1,
NP_001339300.1,
NP_001339287.1,
XP_006718687.1,
NP_001339302.1,
NP_001339280.1,
XP_024304370.1,
XP_006718671.1,
NP_001339294.1,
NP_001339285.1,
NP_001339276.1,
NP_001339288.1,
XP_006718684.1,
NP_001339306.1,
XP_011543443.1,
NP_001339286.1,
NP_001157633.1,
NP_001339301.1,
NP_001339283.1,
XP_016873458.1,
NP_001157634.1,
NP_001339281.1,
NP_001339292.1,
XP_006718686.1,
NP_001157636.1,
NP_001339289.1,
NP_001339297.1,
XP_016873463.1,
XP_006718685.1,
NP_001157635.1,
NP_001339299.1,
XP_011543441.1,
XP_011543440.1,
XP_006718675.1,
NP_001339293.1,
XP_006718690.1,
XP_024304369.1,
NP_001339291.1,
NP_001339298.1,
NP_001339295.1,
NP_001339309.1,
NP_001339277.1,
NP_001339308.1,
NP_001339307.1,
NP_001339279.1,
XP_011543439.1,
NP_001339305.1,
NP_001339303.1,
NP_001157632.1,
NP_001339304.1,
NP_001339290.1,
NP_060782.2
|
| Others |
UniRef100:
UniRef100_A0A024R5F3,
UniRef100_Q5H9R7,
UniRef100_H7BXH2
UniRef90:
UniRef90_Q5H9R7,
UniRef90_A0A024R5F3,
UniRef90_H7BXH2
UniRef50:
UniRef50_Q5H9R7
UniGene:
Hs.503022
CCDS:
CCDS53675.1,
CCDS53673.1,
CCDS8182.1,
CCDS53674.1,
CCDS53672.1,
CCDS53671.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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