| Type | Description |
|---|---|
| Definition | eukaryotic translation initiation factor 4A2 |
| Date | Results | Publications |
|---|---|---|
| 2020-03-21 10:35:00 | exerts its repressive effect on translation initiation by binding purine-rich motifs which are enriched in the 5'UTR of target mRNAs directly upstream of the AUG start codon | 31791371 |
| 2019-12-14 11:57:00 | Data show that incorporation of ATP-dependent RNA helicase eIF4A-2 (eIF4A2) into the CCR4-NOT complex inhibits CCR4-NOT transcription complex subunit 7 (CNOT7) deadenylation activity. | 31180491 |
| 2019-11-16 11:48:00 | high EIF4A2 expression predicts poor prognosis of CRC patients and is associated with distant metastasis and poor response to oxaliplatin. Knocking-down EIF4A2 inhibits sphere formation and experimental metastasis, as well as oxaliplatin resistance in CRC. | 31088567 |
| 2019-08-31 10:25:00 | EIF4A2 was confirmed as a potential target of miR-5195-3p. MicroRNA-5195-3p enhances the chemosensitivity of triple-negative breast cancer (TNBC) to paclitaxel (PTX) by downregulating EIF4A2. | 31308851 |
| 2019-05-04 10:20:00 | Eukaryotic translation initiation factor 4A2 (eIF4A2) is necessary for efficient HIV-1 replication in human lymphoid cell line. eIF4A2 depletion reduces the efficiency of viral cDNA synthesis with virion entry into target cells being unaffected. Depletion of eIF4A2 also inhibits HIV-1 spreading infection in a knockdown level-dependent manner. | 29842983 |
| Type | IDs |
|---|---|
| Synonymous | BM-010, DDX2B, EIF4A, EIF4F, eIF-4A-II, eIF4A-II |
| Gene |
UniProtKB-ID:
IF4A2_HUMAN
UniprotKB:
Q14240
UniParc:
UPI0000062309,
UPI0000000DD2
EMBL:
BC013708,
BC015842,
BC012547,
CH471052,
AC112907,
BT009860,
BC048105,
D30655
Ensembl:
ENSG00000156976
KO:
hsa:1974
|
| Nucleutide sequences |
EMBL-CDS:
AAP88862.1,
EAW78172.1,
AAH12547.1,
BAA06336.1,
AAH15842.1,
AAH48105.1,
AAH13708.1,
EAW78177.1
Ensembl_TRS:
ENST00000323963,
ENST00000440191
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000398370,
ENSP00000326381
RefSeq:
NP_001958.2
|
| Others |
UniRef100:
UniRef100_Q14240
UniRef90:
UniRef90_Q14240
UniRef50:
UniRef50_Q14240
UniGene:
Hs.518475,
Hs.599481
CCDS:
CCDS3282.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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