| Type | Description |
|---|---|
| Definition | inhibitor of nuclear factor kappa B kinase regulatory subunit gamma |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:24:00 | Antagonizing binding of cell cycle and apoptosis regulatory protein 1 to the NEMO/IKKgamma protein enhances the anticancer effect of chemotherapy. | 32024692 |
| 2020-10-24 14:09:00 | DNA-PK: gatekeeper for IKKgamma/NEMO nucleocytoplasmic shuttling in genotoxic stress-induced NF-kappaB activation. | 31932854 |
| 2020-08-12 12:52:00 | The spectrum of pathologic manifestation in female incontinentia pigmenti adult patients caused by pathogenic variant in IKBKG has been reported. | 31119873 |
| 2020-07-18 11:56:00 | Incontinentia pigmenti (IP) is an X-linked dominant disease,generally lethal in males, caused by variants of theIKBKG/NEMOgene , which encodes for IKK-gamma/NEMO, essential for NF-kappaB activation | 31289372 |
| 2020-06-06 13:19:00 | This study shows that a highly conserved central region of NEMO termed the intervening domain (IVD, amino acids 112-195) plays a key role in NEMO function. This articles proposes a model in which the IVD is required for a conformational change in NEMO that is necessary for its ability to direct phosphorylation of IkappaBalpha by IKK-beta. | 31145594 |
| Type | IDs |
|---|---|
| Synonymous | AMCBX1, EDAID1, FIP-3, FIP3, Fip3p, IKK-gamma, IKKAP1, IKKG, IMD33, IP, IP1, IP2, IPD2, NEMO, ZC2HC9 |
| Gene |
UniProtKB-ID:
NEMO_HUMAN,
A0A087X1B1_HUMAN
UniprotKB:
Q9Y6K9,
A0A087X1B1
UniParc:
UPI0000370010,
UPI00001A36E3,
UPI0000000CC4,
UPI0001B791CB
EMBL:
AF062089,
BC050612,
AJ271718,
AC244090,
BC000299,
AF277315,
BT019621,
AY114157,
AF074382,
BC012114,
BC046922,
AF091453,
AF261086,
AK000593
Ensembl:
ENSG00000269335
KO:
hsa:8517
|
| Nucleutide sequences |
EMBL-CDS:
AAH00299.1,
AAF99679.1,
AAV38427.1,
AAM44073.1,
AAC36330.1,
CAB93146.1,
AAL27012.1,
AAD38081.1,
AAH50612.1,
AAH12114.1,
AAD12183.1,
AAH46922.1
Ensembl_TRS:
ENST00000594239,
ENST00000611176,
ENST00000611071,
ENST00000618670,
ENST00000617207
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000478616,
ENSP00000479662,
ENSP00000471166,
ENSP00000483825,
ENSP00000484023
RefSeq:
NP_003630.1,
NP_001364243.1,
NP_001364244.1,
NP_001308325.1,
NP_001093327.1,
NP_001364242.1,
NP_001364241.1,
NP_001308326.1,
NP_001138727.1,
NP_001093326.2
|
| Others |
UniRef100:
UniRef100_Q9Y6K9,
UniRef100_A0A087X1B1
UniRef90:
UniRef90_Q9Y6K9,
UniRef90_A0A2K6GM78
UniRef50:
UniRef50_Q9Y6K9
UniGene:
Hs.43505
CCDS:
CCDS14757.1,
CCDS48196.1,
CCDS48197.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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