| Type | Description |
|---|---|
| Definition | phospholipase A2 group IVA |
| Date | Results | Publications |
|---|---|---|
| 2020-04-18 10:40:00 | PLA2G4A upregulation has multiple effects on the malignant phenotype of Acute Myeloid Leukemia cells together with its partners. | 32077754 |
| 2020-02-22 10:48:00 | Tyr96 plays a key role in lipid headgroup recognition via cation-pi interaction with the phosphatidylcholine trimethylammonium group. Mutagenesis analyses confirm that Tyr96 and Asn65 function in phosphatidylcholine binding selectivity by the C2-domain and in the regulation of cPLA2alpha activity. | 31050338 |
| 2020-02-08 11:29:00 | It catalyzes the initial step in the generation of lipid mediators, including eicosanoids and lysophospholipids, in the progression of hepatic fibrosis. | 31474631 |
| 2020-01-11 12:20:00 | cPLA2a could promote osteosarcoma cell invasion via inducing the epithelial-mesenchymal transition process, indicating that cPLA2a was an independent prognostic biomarker and may be an effective drug target for osteosarcoma | 31003849 |
| 2019-08-10 11:36:00 | The expression of cPLA2alpha varies in multiple glioblastoma cell lines and is associated with chemoresistance rather than tumor development. cPLA2alpha depletion moderately inhibits glioblastoma growth and survival but remarkably sensitizes chemo-resistant glioblastoma cells to several chemotherapeutic agents. | 30360807 |
| Type | IDs |
|---|---|
| Synonymous | PLA2G4, cPLA2, cPLA2-alpha |
| Gene |
UniProtKB-ID:
PA24A_HUMAN,
B4DZI4_HUMAN
UniprotKB:
P47712,
B4DZI4
UniParc:
UPI0000203D76,
UPI00017A83D4
EMBL:
AL022147,
BC114340,
M72393,
M68874,
AY552098,
AK302938,
AL049797
Ensembl:
ENSG00000116711
KO:
hsa:5321
|
| Nucleutide sequences |
EMBL-CDS:
AAI14341.1,
AAA60105.1,
AAB00789.1,
AAS45712.1,
BAG64096.1
Ensembl_TRS:
ENST00000367466
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000356436
RefSeq:
NP_077734.2,
NP_001298122.2,
XP_005245324.2,
XP_011507944.1
|
| Others |
UniRef100:
UniRef100_B4DZI4,
UniRef100_P47712
UniRef90:
UniRef90_P47712
UniRef50:
UniRef50_P47712
UniGene:
Hs.497200
CCDS:
CCDS1372.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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