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23534 TNPO3

23534

TNPO3

transportin 3

protein-coding

Homo sapiens

基因描述

Type Description
Definition transportin 3

研究结论

Date Results Publications
2020-12-05 13:00:00 TNPO3-Mediated Nuclear Entry of the Rous Sarcoma Virus Gag Protein Is Independent of the Cargo-Binding Domain. 32581109
2020-09-19 16:25:00 An Allele-Specific Functional SNP Associated with Two Systemic Modulates IRF5 Expression by Long-Range Chromatin Loop Formation. 31421124
2020-06-13 12:25:00 our results support a model in which miR-128 is expressed in primary HIV-1 target cells, is a type I IFN response gene, and functions as a novel antiviral defense mechanism during HIV-1 infection, partly by repressing the nuclear import factors TNPO3 and by inhibiting HIV-1 replication and viral spreading 31341054
2020-01-18 12:10:00 TNPO3 mutant protein expressed in limb girdle muscular dystrophy 1F cells is the second genetic defect leading to strong HIV-1 restriction. 31465518
2019-11-30 12:15:00 The crystal structure of the RSLD-TNPO3 complex revealed potential CPSF6 interaction residues, which were confirmed to mediate TNPO3 binding and CPSF6 nuclear import. Both binding and nuclear import were independent of RSLD phosphorylation, though a hyperphosphorylated mimetic mutant failed to bind TNPO3 and mislocalized to the cell cytoplasm 30916345

名称对应

Type IDs
Synonymous IPO12, LGMD1F, LGMDD2, MTR10A, TRN-SR, TRN-SR2, TRNSR
Gene
UniProtKB-ID: TNPO3_HUMAN, B3KMX1_HUMAN, A0A024R794_HUMAN
UniprotKB: Q9Y5L0, B3KMX1, A0A024R794
UniParc: UPI0000072FAB, UPI0000498128, UPI0001627803, UPI000015F4E4, UPI0001B79349
EMBL: BC009221, AC018639, AK022910, AK225999, CH236950, AJ133769, CH471070, AF145029, AC025594
Ensembl: ENSG00000064419
KO: hsa:23534
Nucleutide sequences
EMBL-CDS: AAD38537.1, AAH09221.2, CAB42643.1, EAL24106.1, BAG51133.1, EAW83709.1, EAW83710.1
Gene_ORFName: hCG_41664
Ensembl_TRS: ENST00000265388, ENST00000471234
Protein sequencees
Ensembl_PRO: ENSP00000265388, ENSP00000418646
RefSeq: NP_001369148.1, NP_001177957.2, NP_001369150.1, NP_001369146.1, NP_036602.1, NP_001369151.1, NP_001369147.1, NP_001369145.1, NP_001369149.1, NP_001369152.1
Others
UniRef100: UniRef100_Q9Y5L0, UniRef100_B3KMX1
UniRef90: UniRef90_Q9Y5L0, UniRef90_Q9Y5L0-1
UniRef50: UniRef50_Q9Y5L0
UniGene: Hs.193613
CCDS: CCDS55162.1, CCDS5809.1

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