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11016 ATF7

11016

ATF7

activating transcription factor 7

protein-coding

Homo sapiens

基因描述

Type Description
Definition activating transcription factor 7

研究结论

Date Results Publications
2019-05-18 12:37:00 Results found that ATF7 is upregulated in hepatocellular carcinoma (HCC) tissue. Its expression is regulated by miR-340 which directly binds to the mRNA encoding ATF7. Under HBV infection, miR-340 is downregulated resulting in increasing ATF7 expression, leading to enhanced cell proliferation and inhibition of apoptosis. 30891870
2018-11-03 10:38:00 ATF7 is a direct target of miR-103a-3p. In a stomach cancer cohort,miR-103a-3p expression was inversely correlated with ATF7 expression. Silencing ATF7 showed similar cellular and molecular effects as miR-103a-3p overexpression, namely, increased GC cell proliferation, improved CDK2 expression and decreased P27 expression. 29754469
2017-09-30 11:39:00 knockdown of the mammalian homologs of PDK1 and ATF7 in HEK293 cells resulted in changes in metallothionein expression, suggesting that this pathway was evolutionarily conserved 28632756
2016-08-20 11:43:00 CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas. 26747248
2016-05-28 12:20:00 mitotic stabilized ATF7 protein re-localizes onto chromatin at the end of telophase and contributes to induce the cyclin D1 gene expression. 26101806

名称对应

Type IDs
Synonymous ATFA
Gene
UniProtKB-ID: ATF7_HUMAN
UniprotKB: P17544
UniParc: UPI000002A477, UPI0000161877, UPI00000724F9, UPI0000126230, UPI0000D49DED, UPI000002A476
EMBL: BC140006, AK298853, BC042363, CH471054, AC073594, X52943, X57197, AC023509, BC136302
Ensembl: ENSG00000170653
KO: hsa:11016
Nucleutide sequences
EMBL-CDS: AAI36303.1, EAW96724.1, CAA40483.1, AAI40007.1, BAG60976.1, EAW96723.1, CAA37118.1, AAH42363.1
Ensembl_TRS: ENST00000456903, ENST00000420353, ENST00000548446, ENST00000548118, ENST00000591397
Protein sequencees
Ensembl_PRO: ENSP00000399465, ENSP00000449938, ENSP00000465192, ENSP00000456858, ENSP00000387406
RefSeq: NP_001353485.1, NP_001353491.1, NP_001193611.1, NP_001123532.1, NP_001353490.1, NP_001353484.1, NP_001353487.1, NP_001353492.1, NP_006847.1, NP_001193612.1
Others
UniRef100: UniRef100_P17544
UniRef90: UniRef90_P17544
UniRef50: UniRef50_P17544
UniGene: Hs.12286, Hs.633602
CCDS: CCDS58238.1, CCDS44906.1

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