| Type | Description |
|---|---|
| Definition | SUB1 homolog, transcriptional regulator |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 12:51:00 | PC4 is essential for genomic integrity and autophagy regulation. | 31169983 |
| 2019-11-30 10:16:00 | PC4 emerges as a global co-regulator of p53 and a therapeutic target against pathogeneses where the p53-dependent cell death process plays a crucial role. | 31236588 |
| 2019-08-17 10:51:00 | this study reveals for the first time that PC4 promotes breast cancer progression by directly regulating c-Myc transcription to promote Warburg effect, implying a novel therapeutic target for breast cancer. | 30992017 |
| 2019-08-10 12:34:00 | PC4 expression correlated with radiosensitivity and was an independent prognostic factor of progression-free survival (PFS) in patients with NSCLC. | 29522271 |
| 2018-11-17 10:06:00 | Study shows that PC4 might repress RNA pol II recruitment and transcription of replication-dependent histone genes in order to maintain the balance between histone gene expression and DNA synthesis. Moreover, PC4 might promote the interaction of cleavage and polyadenylation complex with histone pre-mRNAs, that might impede with the recruitment of histone cleavage complex. | 30053800 |
| Type | IDs |
|---|---|
| Synonymous | P15, PC4, p14 |
| Gene |
UniProtKB-ID:
TCP4_HUMAN,
Q6IBA2_HUMAN
UniprotKB:
P53999,
Q6IBA2
UniParc:
UPI0000044938
EMBL:
BC009610,
BC010537,
AK311754,
BC105972,
BC022339,
CH471118,
BC018189,
CR456902,
U12979,
X79805
Ensembl:
ENSG00000113387
KO:
hsa:10923
|
| Nucleutide sequences |
EMBL-CDS:
CAA56200.1,
AAH09610.1,
AAH22339.1,
AAH10537.1,
AAA20980.1,
AAH18189.1,
EAX10795.1,
CAG33183.1,
EAX10794.1,
EAX10793.1,
EAX10796.1,
BAG34697.1,
AAI05973.1
Gene_ORFName:
hCG_1781938
Ensembl_TRS:
ENST00000506237,
ENST00000502897,
ENST00000515355,
ENST00000265073,
ENST00000512913
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000427100,
ENSP00000426850,
ENSP00000422078,
ENSP00000265073,
ENSP00000422806
RefSeq:
XP_016864475.1,
XP_016864476.1,
NP_006704.3,
XP_011512246.1
|
| Others |
UniRef100:
UniRef100_P53999
UniRef90:
UniRef90_P53999
UniRef50:
UniRef50_P53999
UniGene:
Hs.229641
CCDS:
CCDS3897.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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