| Type | Description |
|---|---|
| Definition | eukaryotic translation initiation factor 3 subunit C |
| Date | Results | Publications |
|---|---|---|
| 2020-09-19 16:23:00 | Eukaryotic initiation factor 3, subunit C silencing inhibits cell proliferation and promotes apoptosis in human ovarian cancer cells. | 31316002 |
| 2020-04-11 10:47:00 | circ_0067934 promotes cervical cancer progression via miR-545/EIF3C axis. | 30362562 |
| 2020-04-04 11:13:00 | eIF3C expression was upregulated in renal cell carcinoma (RCC) tissues and cell lines. Depletion of eIF3C reduced tumor cell proliferation and arrested them at the G1 stage, thus promoting their apoptosis in vitro. Depletion of eIF3C also inhibited the formation and growth of tumor cell xenografts in nude mice. Study demonstrated that upregulated eIF3C expression contributed to the development and progression of RCC. | 31638200 |
| 2020-03-21 11:16:00 | Whereas the eIF3c knockdown reduces it, downregulation of eIF3k or eIF3l increases mRNA recruitment, suggesting that the latter subunits possess a regulatory potential. Altogether this study provides new insights into the role of human eIF3 in the initial assembly steps of the translational machinery | 31863585 |
| 2019-07-13 10:45:00 | EIF3C overexpression was correlated to age and tumor stage in prostate cancer patients and indicated poor survival. The proliferation, migration, and invasiveness of PC3 cells were all inhibited after EIF3C knockdown. Phosphorylation level of PI3K and Akt and total NF-kappaB and Myc decreased after EIF3C knockdown. Therefore, EIF3C at least partially regulates the activity of PI3K/Akt/NF-kappaB signaling pathway in PC3... | 31181967 |
| Type | IDs |
|---|---|
| Synonymous | EIF3CL, EIF3S8, eIF3-p110 |
| Gene |
UniProtKB-ID:
EIF3C_HUMAN,
A0A024QYU9_HUMAN
UniprotKB:
Q99613,
A0A024QYU9
UniParc:
UPI000012D309,
UPI0002466EB6
EMBL:
AC002544,
BC071705,
BC000533,
CH878380,
AK303790,
BC001571,
BC157842,
U46025,
BC157849,
AC145285,
AK292155,
U91326,
AK000739,
BT007335
Ensembl:
ENSG00000184110
KO:
hsa:8663
|
| Nucleutide sequences |
EMBL-CDS:
EAW50492.1,
AAI57843.1,
BAA91352.1,
BAG64747.1,
AAI57850.1,
BAF84844.1,
AAH01571.1,
AAC27674.1,
AAH00533.1,
AAP35999.1,
AAC27426.1,
AAD03462.1,
AAH71705.1,
EAW50494.1,
EAW50496.1
Gene_ORFName:
hCG_201185
Ensembl_TRS:
ENST00000331666,
ENST00000395587,
ENST00000564243,
ENST00000566501,
ENST00000566866
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000332604,
ENSP00000456416,
ENSP00000378953,
ENSP00000457963,
ENSP00000457418
RefSeq:
NP_001254503.1,
XP_016879303.1,
NP_001032897.1,
NP_003743.1,
NP_001273407.1,
NP_001186071.1
|
| Others |
UniRef100:
UniRef100_Q99613
UniRef90:
UniRef90_Q99613
UniRef50:
UniRef50_Q99613
UniGene:
Hs.567374
CCDS:
CCDS10638.1,
CCDS66993.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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