| Type | Description |
|---|---|
| Definition | argininosuccinate synthase 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-13 10:11:00 | Neonatal factors related to survival and intellectual and developmental outcome of patients with early-onset urea cycle disorders. | 32273051 |
| 2019-12-14 11:45:00 | The combination of ADI-PEG20 with temozolomide (TMZ) demonstrates enhanced effects in both ASS1 negative and ASS1 positive backgrounds.Our data provide proof of principle for a therapeutic strategy for GBM using peripheral blood arginine depletion that does not require BBB passage of drug and is well tolerated | 30546006 |
| 2019-12-07 12:28:00 | Citrullinemia type I (CTLN1) is a rare autosomal recessive disorder of the urea cycle caused by a deficiency in the argininosuccinate synthetase (ASS1) enzyme due to mutations in the ASS1 gene. | 31208364 |
| 2019-08-10 11:02:00 | Overexpression of ASS1 inhibits hepatocellular carcinoma progression by inactivating the pathway, which subsequently decreases the expression of ID1. | 30883650 |
| 2019-05-25 11:46:00 | Arginine starvation induces p300 dissociation, allowing histone HDAC2 and cofactor Sin3A to deacetylate these histones at the ASS1 promoter, thereby facilitating HIF-1alpha-proteasomal complex, driven by PHD2, to degrade HIF-1alpha in situ. | 28883660 |
| Type | IDs |
|---|---|
| Synonymous | ASS, CTLN1 |
| Gene |
UniProtKB-ID:
ASSY_HUMAN,
Q5T6L4_HUMAN
UniprotKB:
P00966,
Q5T6L4
UniParc:
UPI00000015D6
EMBL:
L00079,
BC021676,
L00083,
L00082,
L00081,
M34903,
KU177923,
L00080,
X01630,
AK027126,
L00084,
AY034076,
BC009243,
AK315093,
GQ891434,
CH471090
Ensembl:
ENSG00000130707
KO:
hsa:445
|
| Nucleutide sequences |
EMBL-CDS:
AAA51783.1,
AAA51782.1,
AAH21676.1,
AAK67487.1,
CAA25771.1,
AAH09243.1,
ADO22296.1,
EAW87935.1,
ALQ33381.1,
EAW87932.1,
BAG37558.1
Gene_ORFName:
hCG_31245
Ensembl_TRS:
ENST00000352480,
ENST00000372394,
ENST00000372393
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000253004,
ENSP00000361469,
ENSP00000361471
RefSeq:
NP_446464.1,
NP_000041.2,
XP_005272257.1,
XP_016870218.1,
XP_011517007.1
|
| Others |
UniRef100:
UniRef100_P00966
UniRef90:
UniRef90_P00966
UniRef50:
UniRef50_P00966
UniGene:
Hs.160786
CCDS:
CCDS6933.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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