| Type | Description |
|---|---|
| Definition | latexin |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:51:00 | The putative tumour suppressor protein Latexin is secreted by prostate luminal cells and is downregulated in malignancy. | 30914656 |
| 2019-03-09 11:48:00 | Deletion of latexin in vivo increases HSC repopulation capacity and survival, expands the entire hematopoietic system, and mitigates myelosuppression. Latexin inactivation downregulates thrombospondin 1 (Thbs1). It inhibits nuclear translocation of ribosomal protein subunit 3 (Rps3), a novel latexin-binding protein, and sensitizes hematopoietic cells to radiation-induced cell death. | 29608488 |
| 2017-10-21 10:22:00 | Results identified that LXN expression inversely modulates taxane-chemoresistance in the PC-3 prostate cancer cell line. Inhibition of LXN expression in the bone microenvironment promotes chemoresistance, in part through a methylation-dependent mechanism. | 28087740 |
| 2016-10-22 11:35:00 | Results show that Lxn expression was clearly decreased in the pancreatic ductal adenocarcinoma tissues suggesting it that as a tumor suppressor that targets CD133-positive cancer cells. | 26530530 |
| 2016-01-16 12:02:00 | Lxn protein and mRNA expression levels in CD133+ miapaca-2 cells were significantly lower than those in CD133- cells. | 25551472 |
| Type | IDs |
|---|---|
| Synonymous | ECI, TCI |
| Gene |
UniProtKB-ID:
LXN_HUMAN
UniprotKB:
Q9BS40
UniParc:
UPI000006FB86
EMBL:
BC008438,
AF087851,
AC080013,
AF282626,
AF282594,
AC025033,
BC005346,
AF303587
Ensembl:
ENSG00000079257
KO:
hsa:56925
|
| Nucleutide sequences |
EMBL-CDS:
AAH05346.1,
AAL09331.1,
AAF82807.1,
AAK69518.1,
AAH08438.1,
AAP97162.1
Ensembl_TRS:
ENST00000264265
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000264265
RefSeq:
XP_016862365.1,
NP_064554.3
|
| Others |
UniRef100:
UniRef100_Q9BS40
UniRef90:
UniRef90_Q9BS40
UniRef50:
UniRef50_Q9BS40
UniGene:
Hs.478067
CCDS:
CCDS3183.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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