| Type | Description |
|---|---|
| Definition | GRIP and coiled-coil domain containing 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-03-21 11:22:00 | The co-localization of M6PR and of GCC2 with ASOs is influenced by the PS modifications, which have been shown to enhance the affinity of ASOs for proteins, suggesting that localization of these proteins to LEs is mediated by ASO-protein interactions. Reduction of M6PR levels also decreased PS-ASO activity in mouse cells and in livers of mice treated subcutaneously with PS-ASO, indicating a conserved mechanism. | 31840180 |
| 2017-05-13 10:46:00 | In light of existing report suggesting critical role of Nef-GCC185 interaction reveals valuable mechanistic insights affecting specific protein transport pathway in docking of late endosome derived Rab9 bearing transport vesicle at TGN elucidating role of Nef during viral pathogenesis. | 27105913 |
| 2016-10-08 11:43:00 | These unexpected features support a model in which GCC185 collapses onto the Golgi surface, perhaps by binding to Rab GTPases, to mediate vesicle tethering. | 26653856 |
| 2012-04-21 12:02:00 | Deletion of the ARL4A-interacting region of GCC185 results in inability to maintain Golgi structure and modulate endosome-to-Golgi transport. | 22159419 |
| 2012-01-28 11:36:00 | Two distinct domains of GCC185 are needed either for Golgi structure maintenance or transport vesicle tethering. The domain needed for vesicle tethering binds to the clathrin adaptor AP-1. | 21875948 |
| Type | IDs |
|---|---|
| Synonymous | GCC185, RANBP2L4, REN53 |
| Gene |
UniProtKB-ID:
GCC2_HUMAN,
B3KR21_HUMAN
UniprotKB:
Q8IWJ2,
B3KR21
UniParc:
UPI0000D48D61,
UPI000049DF0C,
UPI0001B7988D
EMBL:
AB002334,
CH471182,
BC037774,
AF432211,
AF273042,
AC068941,
BC146789,
AC012487,
AK090813
Ensembl:
ENSG00000135968
KO:
hsa:9648
|
| Nucleutide sequences |
EMBL-CDS:
EAW53882.1,
AAG34902.1,
BAA20794.2,
AAH37774.1,
AAL99918.1,
AAX88838.1,
AAI46790.1,
BAG52233.1
Ensembl_TRS:
ENST00000482325,
ENST00000309863
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000419969,
ENSP00000307939
RefSeq:
NP_852118.2,
XP_006712934.1,
XP_006712933.1,
XP_006712935.1,
XP_011510515.1
|
| Others |
UniRef100:
UniRef100_Q8IWJ2
UniRef90:
UniRef90_Q8IWJ2
UniRef50:
UniRef50_Q8IWJ2
UniGene:
Hs.436505,
Hs.469630
CCDS:
CCDS33268.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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