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10525 HYOU1

10525

HYOU1

hypoxia up-regulated 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition hypoxia up-regulated 1

研究结论

Date Results Publications
2020-07-18 11:28:00 Study found that the expression levels of HYOU1 were significantly upregulated in both EOC tissues and cell lines, and associated with advanced FIGO stage, LN metastasis, and shorter overall survival. In addition, high HYOU1 expression as an unfavorable factor for overall survival. Its inhibition of HYOU1 suppressed tumor proliferation and colony formation, as well as the migratory and invasive capacity. 31173282
2020-02-29 11:26:00 Serum level of ORP150 was significantly up-regulated in the diabetic nephropathy patients.ORP150 levels were positively correlated with proteinuria burden via mediating VEGF in the diabetic nephropathy. 31028725
2020-01-18 13:01:00 we demonstrate that in the ER,Akita forms detergent-insoluble protein aggregates that entrap WT proinsulin. Strikingly, we find that two distinct ER quality-control pathways are deployed to limit the levels of these aggregates. First, Grp170 acts to prevent formation of detergent-insoluble Akita aggregates, which otherwise recruit and capture WT proinsulin. 31176671
2019-03-02 10:42:00 ORP150 and CHIP demonstrate antagonism under normal and stress conditions wherein they inversely regulate each other thus affecting BACE1 level. 29266373
2018-04-07 10:55:00 These results strongly suggest that AMPK can activate ORP150 through FOXO1 pathway and confer protection against endoplasmic reticulum stress - induced apoptosis of airway epithelial cells following exposure to cigarette smoke extract. 29448096

名称对应

Type IDs
Synonymous GRP-170, Grp170, HSP12A, IMD59, ORP-150, ORP150
Gene
UniProtKB-ID: HYOU1_HUMAN, B7Z766_HUMAN, Q6IN67_HUMAN, A0A494C039_HUMAN, B3KXH0_HUMAN, A0A384P5T6_HUMAN, B7Z602_HUMAN
UniprotKB: Q9Y4L1, B7Z766, Q6IN67, A0A494C039, B3KXH0, A0A384P5T6, B7Z602
UniParc: UPI000387BCD2, UPI00004A2828, UPI000191520B, UPI0000130F72, UPI0001914F7A, UPI0000378350, UPI00019154B5
EMBL: GQ900898, AK127324, AK299648, AB009979, AK222756, AK304264, U65785, DQ372932, GQ891455, AK314178, KF511132, AK301514, AP003392, DQ350134, EF444986, BC072436, KF510357
Ensembl: ENSG00000280682, ENSG00000149428
KO: hsa:10525
Nucleutide sequences
EMBL-CDS: AAC50947.1, ACA06002.1, ABC75106.1, BAF80348.1, BAG36860.1, BAD96476.1, ABD14370.1, BAH14145.1, BAH13502.1, AAH72436.1, BAG54482.1, ADO22317.1, ADO22415.1, BAH13088.1
Ensembl_TRS: ENST00000630669, ENST00000617285, ENST00000652093
Protein sequencees
Ensembl_PRO: ENSP00000480150, ENSP00000486825, ENSP00000498353
RefSeq: XP_005271449.1, XP_016872585.1, XP_005271450.1, XP_005271451.1, NP_006380.1, XP_016872586.1, XP_016872584.1, NP_001124463.1
Others
UniRef100: UniRef100_Q9Y4L1, UniRef100_B7Z766, UniRef100_A0A494C039, UniRef100_B3KXH0, UniRef100_B7Z602, UniRef100_Q6IN67
UniRef90: UniRef90_Q9Y4L1-2, UniRef90_B7Z602, UniRef90_G3QYC5, UniRef90_Q9Y4L1
UniRef50: UniRef50_A0A337SEZ3, UniRef50_Q9Y4L1-2, UniRef50_Q9Y4L1
UniGene: Hs.277704
CCDS: CCDS8408.1

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