| Type | Description |
|---|---|
| Definition | tRNA-histidine guanylyltransferase 1 like |
| Date | Results | Publications |
|---|---|---|
| 2018-02-10 10:34:00 | Study proposes that homozygosity for the p.Val55Ala mutation in tRNA-histidine guanylyltransferase 1 like (THG1L) is the cause of the abnormal mitochondrial network in the patient fibroblasts, likely by interfering with THG1L activity towards MFN2. | 27307223 |
| 2015-12-15 15:26:00 | The high-resolution crystal structure of human Thg1 reveals remarkable structural similarity between canonical DNA/RNA polymerases and eukaryotic Thg1. | 22136300 |
| 2015-01-17 10:46:00 | IHG-1 is a novel regulator of both mitochondrial dynamics and bioenergetic function and contributes to cell survival following oxidant stress. Increased IHG-1 expression may contribute to pathogenesis of diabetic kidney disease. | 25008184 |
| 2012-09-13 15:53:00 | IHG-1 increases mitochondrial biogenesis by promoting PGC-1alpha-dependent processes, potentially contributing to the pathogenesis of renal fibrosis | 21784897 |
| 2011-01-22 10:44:00 | The catalytic domain of Thg1 shares both a common architecture and a two-metal ion-dependent mechanism with canonical 5'-3' DNA polymerases. | 21078997 |
| Type | IDs |
|---|---|
| Synonymous | ICF45, IHG-1, hTHG1 |
| Gene |
UniProtKB-ID:
THG1_HUMAN,
Q9H8R6_HUMAN,
B4E366_HUMAN
UniprotKB:
Q9NWX6,
Q9H8R6,
B4E366
UniParc:
UPI00004804EE,
UPI000006E264,
UPI0000073782
EMBL:
AK223119,
AY463216,
AK021663,
AL136669,
CR533503,
CH471062,
BC001852,
BC023521,
AK000553,
BC001523,
AK023355,
AK304590
Ensembl:
ENSG00000113272
KO:
hsa:54974
|
| Nucleutide sequences |
EMBL-CDS:
CAG38534.1,
EAW61590.1,
CAB66604.1,
BAB13870.1,
AAH23521.1,
AAH01852.2,
EAW61591.1,
AAH01523.2,
BAD96839.1,
BAA91249.1,
AAS21134.1,
BAB14540.1,
BAG65378.1
Ensembl_TRS:
ENST00000231198
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000231198
RefSeq:
NP_001304755.1,
NP_001304754.1,
NP_001304753.1,
NP_060342.2,
XP_016865092.1
|
| Others |
UniRef100:
UniRef100_Q9NWX6,
UniRef100_B4E366
UniRef90:
UniRef90_B4E366,
UniRef90_Q9NWX6
UniRef50:
UniRef50_A0A673VQI7,
UniRef50_Q9NWX6
UniGene:
Hs.353090
CCDS:
CCDS4341.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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