| Type | Description |
|---|---|
| Definition | eukaryotic translation initiation factor 5 |
| Date | Results | Publications |
|---|---|---|
| 2018-02-24 10:31:00 | Translational initiation pathway inhibition could be of clinical utility in male breast cancer patients overexpressing eIF4E and eIF5. With mTOR inhibitors that target this pathway now in the clinic, these biomarkers may represent new targets for therapeutic intervention, although further independent validation is required | 27986751 |
| 2017-12-16 11:00:00 | Data show that eIF5-mimic protein (5MP) represses non-AUG translation by competing with translation initiation factor 5 (eIF5) for the factor eIF2. | 28981728 |
| 2017-06-24 10:44:00 | The down-regulation of the GCN4 expression (Gcn(-) phenotype) in the eIF5(G31R) mutant was not because of leaky scanning defects; rather was due to the utilization of upUUG initiation codons at the 5' regulatory region present between uORF1 and the main GCN4 ORF. | 28385532 |
| 2017-06-10 10:17:00 | overexpression of eIF5 and 5MP induces translation of ATF4 | 27325740 |
| 2016-07-30 11:41:00 | it is eIF5-induced GTP hydrolysis and Pi release that irreversibly trap the 48S complex, and this complex is further stabilized by eIF5B and 60S joining. | 26717981 |
| Type | IDs |
|---|---|
| Synonymous | EIF-5, EIF-5A |
| Gene |
UniProtKB-ID:
IF5_HUMAN,
A0A024R6Q1_HUMAN
UniprotKB:
P55010,
A0A024R6Q1
UniParc:
UPI000012D3A5
EMBL:
BC032866,
BX537367,
AL080102,
BC007728,
U49436,
CH471061,
AK026933
Ensembl:
ENSG00000100664
KO:
hsa:1983
|
| Nucleutide sequences |
EMBL-CDS:
CAD97610.1,
AAC50572.1,
AAH32866.1,
AAH07728.1,
EAW81809.1,
BAB15593.1,
CAB45711.1,
EAW81811.1,
EAW81810.1
Gene_ORFName:
hCG_25496
Ensembl_TRS:
ENST00000392715,
ENST00000216554,
ENST00000558506
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000216554,
ENSP00000376477,
ENSP00000453743
RefSeq:
NP_892116.2,
NP_001960.2
|
| Others |
UniRef100:
UniRef100_P55010
UniRef90:
UniRef90_P55010
UniRef50:
UniRef50_P55010
UniGene:
Hs.433702,
Hs.741278
CCDS:
CCDS9980.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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