| Type | Description |
|---|---|
| Definition | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:21:00 | PFKFB2 regulates glycolysis and proliferation in pancreatic cancer cells. | 32415418 |
| 2020-06-27 11:51:00 | miR-613 served as a tumor suppressor by targeting PFKFB2, indicating that detecting miR-613 and modulation of miR-613 expression could be potential marker and clinical approach in gastric cancer patients | 31122697 |
| 2020-04-25 12:00:00 | This study aims to characterise the expression and phosphorylation of isozymes of the key glycolytic regulatory protein, 6-phosphofructokinase-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2), in urinary exosomes of subjects with pre-eclampsia . | 30819197 |
| 2019-07-13 11:01:00 | Lower PFKFB2 methylation levels was an independent factor of high relapse risk (Hazard Ratio = 3.2; CI95% = 1.19.5). PFKFB2 promoter methylation analysis has potential applicability to better stratify well-differentiated thyroid carcinomas (WDTC) patients according to the recurrence risk, independently of BRAF and TERT mutations. | 30884810 |
| 2019-05-18 10:15:00 | these results indicate that RSK-mediated phosphorylation of PFKFB2 plays a key role in the metabolism and growth of BRAF-mutated melanomas.Significance: RSK promotes glycolytic metabolism and the growth of BRAF-mutated melanoma by driving phosphorylation of an important glycolytic enzyme | 29440170 |
| Type | IDs |
|---|---|
| Synonymous | PFK-2/FBPase-2 |
| Gene |
UniProtKB-ID:
F262_HUMAN
UniprotKB:
O60825
UniParc:
UPI000012A3F0,
UPI000002A942
EMBL:
BC075076,
BC069350,
BC069586,
AF470623,
BC075075,
AB044805,
BC069385,
BC112103,
CH471100,
BC069600,
AJ005577,
AK292883,
BC112105,
AJ005578,
BC069583,
AL445493
Ensembl:
ENSG00000123836
KO:
hsa:5208
|
| Nucleutide sequences |
EMBL-CDS:
AAH69385.1,
BAF85572.1,
CAA06605.1,
AAH75076.1,
AAH69583.1,
AAH69600.1,
AAI12106.1,
BAB19681.1,
CAA06606.1,
AAH75075.1,
AAL99386.1,
AAH69586.1,
AAH69350.1,
AAI12104.1,
EAW93508.1
Ensembl_TRS:
ENST00000367079,
ENST00000367080
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000356047,
ENSP00000356046
RefSeq:
NP_006203.2,
XP_024303425.1,
XP_024303423.1,
NP_001018063.1,
XP_024303422.1,
XP_024303424.1,
XP_005273219.1
|
| Others |
UniRef100:
UniRef100_O60825
UniRef90:
UniRef90_O60825
UniRef50:
UniRef50_O60825
UniGene:
Hs.282702
CCDS:
CCDS31003.1,
CCDS31004.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员