| Type | Description |
|---|---|
| Definition | cell division cycle 37 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-02 11:42:00 | results demonstrated DDO-5936 as an identified specific small-molecule inhibitor of the Hsp90-Cdc37 PPI that could be used to comprehensively investigate alternative approaches targeting Hsp90 chaperone cycles for cancer therapy. | 31555737 |
| 2019-11-30 12:19:00 | The results suggested that more complicated mechanisms might be necessary to explain the phosphorylation-activated interaction of Cdc37 with various kinases. | 31226489 |
| 2019-01-26 11:37:00 | results of this integrative computational study are compared with a wide range of structural, biochemical, and cell-based experiments, offering a robust network-centric model of allosteric regulation and client kinase recognition by the Hsp90-Cdc37 chaperone machine | 29432007 |
| 2019-01-26 11:09:00 | Results found that several disease-linked mutations convert FGFR3 to a stronger client of Hsp90/Cdc37. Enhanced interaction with Cdc37 is underpinned by a weakened N-lobe network. Cdc37 binding to unrelated kinases induces their common, extensive remodeling. Kinase remodeling and the kinase/Cdc37 architecture allow recognition by Hsp90. | 29478821 |
| 2018-03-17 10:12:00 | Study showed that Cdc37 gene was up-regulated in human colorectal adenocarcinoma (CRC). Furthermore, knockdown of Cdc37 effectively reduced cell proliferation activity, enhanced apoptosis, and inhibited G1-S transition in CRC cells, and vice versa. For the mechanism, Cdc37 increased CDK4 stability to promote the phosphorylation of RB1, which finally promoted the progression of CRC. | 29288563 |
| Type | IDs |
|---|---|
| Synonymous | P50CDC37 |
| Gene |
UniProtKB-ID:
CDC37_HUMAN,
A0A024R7B7_HUMAN
UniprotKB:
Q16543,
A0A024R7B7
UniParc:
UPI000012723D
EMBL:
BT006796,
U43077,
CH471106,
U63131,
BC000083,
BC008793,
AY864824
Ensembl:
ENSG00000105401
KO:
hsa:11140
|
| Nucleutide sequences |
EMBL-CDS:
AAH00083.1,
AAB63979.1,
EAW84101.1,
AAB04798.1,
AAP35442.1,
AAW34362.1,
AAH08793.1,
EAW84103.1,
EAW84102.1
Gene_ORFName:
hCG_28478
Ensembl_TRS:
ENST00000222005
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000222005
RefSeq:
XP_011525954.1,
NP_008996.1
|
| Others |
UniRef100:
UniRef100_Q16543
UniRef90:
UniRef90_Q16543
UniRef50:
UniRef50_Q16543
UniGene:
Hs.160958
CCDS:
CCDS12237.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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