| Type | Description |
|---|---|
| Definition | translocase of inner mitochondrial membrane domain containing 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-03-21 11:54:00 | Whole exome sequencing of a patient with Leigh-like syndrome identified homozygous protein-truncating variants in TIMMDC1 which was predicted to truncate 61 amino acids at the C-terminus. Functional studies demonstrated a hypomorphic impact of the variant on CI assembly. However, the mutant protein could still rescue CI assembly in TIMMDC1 knockout cells. | 30981218 |
| 2020-02-08 11:35:00 | Data suggest that the hub genes NADH:ubiquinone oxidoreductase subunit B5 (NDUFB5), translocase of inner mitochondrial membrane domain containing 1 (TIMMDC1), and voltage-dependent anion channel 3 (VDAC3) might serve as potential biomarkers for diagnosis and/or therapeutic targets for precise treatment of septic cardiomyopathy (SC) . | 31794266 |
| 2019-08-31 11:36:00 | Findings suggest that TIMMDC1 may play an important role in human gastric cancer development, and its underlying mechanism is not only associated with mitochondrial complex I inhibition and reduced mitochondrial respiration, but is also associated with reduced glycolysis activity and the AKT/GSK3beta/beta-catenin signaling pathways. | 30123074 |
| 2015-07-25 10:36:00 | Cell-cycle arrest genes such as CCNG2 and PTEN as well as genes involved in cell migration inhibition, such as TIMP3 and COL3A1, were upregulated after C3orf1 depletion in 95D cells. | 25391042 |
| 2014-04-26 10:52:00 | Quantitative proteomics demonstrated a role for TIMMDC1 in assembly of membrane-embedded and soluble arms of the complex. | 24344204 |
| Type | IDs |
|---|---|
| Synonymous | C3orf1, MC1DN31 |
| Gene |
UniProtKB-ID:
TIDC1_HUMAN,
C9JU35_HUMAN
UniprotKB:
Q9NPL8,
C9JU35
UniParc:
UPI0000209FF6,
UPI0000037B46
EMBL:
AF210057,
CR457158,
AY358633,
AL390077,
CH471052,
BC012341,
AC073352,
AF139077,
AL390094,
CR533524,
AL136622,
AL390090
Ensembl:
ENSG00000113845
KO:
hsa:51300
|
| Nucleutide sequences |
EMBL-CDS:
CAB98251.1,
EAW79568.1,
AAG43510.1,
AAF62372.1,
CAB98201.1,
CAG38555.1,
AAQ88996.1,
AAH12341.1,
CAG33439.1,
EAW79566.1,
CAB66557.1,
CAB98212.1
Gene_ORFName:
UNQ247/PRO284
Ensembl_TRS:
ENST00000494664,
ENST00000493694
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000418803,
ENSP00000419510
RefSeq:
NP_057673.2,
XP_016862045.1
|
| Others |
UniRef100:
UniRef100_Q9NPL8,
UniRef100_C9JU35
UniRef90:
UniRef90_Q9NPL8,
UniRef90_C9JU35
UniRef50:
UniRef50_Q9NPL8,
UniRef50_C9JU35
UniGene:
Hs.477287
CCDS:
CCDS33831.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员