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4048 LTA4H

4048

LTA4H

leukotriene A4 hydrolase

protein-coding

Homo sapiens

基因描述

Type Description
Definition leukotriene A4 hydrolase

研究结论

Date Results Publications
2021-02-20 13:34:00 Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking. 32580506
2020-06-27 12:17:00 the identification of FSCN1-binding partners enhances understanding of the mechanism of FSCN1-mediated malignant phenotypes, and these findings indicate that FSCN1 binds to AIMP1 and LTA4H might promote the progression of laryngeal squamous cell carcinoma . 31287215
2020-02-01 11:01:00 Gliotoxin suppresses the biosynthesis of the potent neutrophil chemoattractant LTB4 by direct interference with LTA4H thereby impairing neutrophil functions in invasive aspergillosis. 30745237
2020-01-11 10:13:00 Low LTA4H expression is associated with antidiastole of tuberculous pleural effusion. 30791695
2019-12-21 10:44:00 the current study demonstrates the ability of eosinophils to express LTA4H and generate LTB4 in response to their activation. Eosinophil derived LTB4 likely contributes to the presence and severity of inflammation in asthma, in particular, those presentations characterized by prominent eosinophilia (and a paucity of neutrophils). 30352167

名称对应

Type IDs
Gene
UniProtKB-ID: LKHA4_HUMAN, A0A140VK27_HUMAN
UniprotKB: P09960, A0A140VK27
UniParc: UPI0001AE6B00, UPI00020CE230, UPI00003FE1B3, UPI0000111C40
EMBL: U27276, U27286, U27290, U27280, U27288, U43410, U27275, U27293, AK298017, U27292, U27281, CH471054, BX647158, U27285, U43411, U27278, U27289, U27287, U27283, AC007298, U27279, BC032528, U27282, U27291, CR457068, HM005567, J02959, U27284, J03459, U27277
Ensembl: ENSG00000111144
KO: hsa:4048
Nucleutide sequences
EMBL-CDS: AAA36177.1, AAH32528.1, AAA36176.1, EAW97559.1, BAG60321.1, CAG33349.1, AAA89077.1, AEE61164.1
Ensembl_TRS: ENST00000228740, ENST00000552789, ENST00000413268
Protein sequencees
Ensembl_PRO: ENSP00000228740, ENSP00000449958, ENSP00000395051
RefSeq: NP_001243573.1, XP_011536651.1, NP_001243572.1, XP_005268928.1, NP_000886.1
Others
UniRef100: UniRef100_P09960
UniRef90: UniRef90_P09960
UniRef50: UniRef50_P09960
UniGene: Hs.524648
CCDS: CCDS58267.1, CCDS58266.1, CCDS9059.1

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