| Type | Description |
|---|---|
| Definition | DNA topoisomerase II binding protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:36:00 | TopBP1 assembles nuclear condensates to switch on ATR signaling. | 33503405 |
| 2021-03-20 13:30:00 | Genome Maintenance by DNA Helicase B. | 32455610 |
| 2020-09-12 16:04:00 | Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response. | 31533931 |
| 2020-08-22 15:31:00 | Switch of TopBP1 Functions by Cdk2 and Akt. | 31964753 |
| 2020-04-18 11:45:00 | TOPBP1 recruitment is mediated by phosphorylation-dependent interactions between three of its BRCT domains and conserved phosphorylated Ser/Thr residues at the C-terminus of the nucleolar phosphoprotein Treacle. | 31913317 |
| Type | IDs |
|---|---|
| Synonymous | Dpb11, TOP2BP1 |
| Gene |
UniProtKB-ID:
TOPB1_HUMAN,
Q05BV8_HUMAN,
A7E2X7_HUMAN,
A0AV47_HUMAN
UniprotKB:
Q92547,
Q05BV8,
A7E2X7,
A0AV47
UniParc:
UPI0000F586D7,
UPI0000D49E1C,
UPI000016789E,
UPI000020A292
EMBL:
BC032633,
AK302584,
BC126209,
BC151237,
AC016255,
AB019397,
AC083905,
D87448
Ensembl:
ENSG00000163781
KO:
hsa:11073
|
| Nucleutide sequences |
EMBL-CDS:
BAA13389.1,
BAH13754.1,
BAA34202.1,
AAH32633.1,
AAI51238.1,
AAI26210.2
Ensembl_TRS:
ENST00000260810
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000260810
RefSeq:
XP_016861126.1,
NP_008958.2,
NP_001350818.1,
XP_011510659.1,
XP_016861125.1
|
| Others |
UniRef100:
UniRef100_Q05BV8,
UniRef100_A7E2X7,
UniRef100_Q92547
UniRef90:
UniRef90_Q92547,
UniRef90_G3TQU6
UniRef50:
UniRef50_G3WDP0,
UniRef50_Q92547
UniGene:
Hs.593379
CCDS:
CCDS46919.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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