| Type | Description |
|---|---|
| Definition | WD repeat domain, phosphoinositide interacting 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:27:00 | A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy. | 32437499 |
| 2021-02-06 13:49:00 | WIPI2 depletion inhibits the growth of hepatocellular carcinoma cells through the AMPK signaling pathway. | 32323845 |
| 2020-03-07 10:03:00 | A mutation in a highly conserved region of WIPI2 is an essential requirement for autophagy to proceed and is found in a large pedigree with global developmental abnormalities. | 30968111 |
| 2019-04-20 10:52:00 | Regulation of the intracellular WIPI2 protein level by mTORC1 and HUWE1 is a key determinant of autophagy flux. | 30340022 |
| 2018-12-01 10:35:00 | Results suggest that Optn potentiates LC3-II production and maturation of the phagophore into the autophagosome, by facilitating the recruitment of the Atg12-5-16L1 complex to Wipi2-positive phagophores. | 29133525 |
| Type | IDs |
|---|---|
| Synonymous | ATG18B, Atg21, CGI-50, WIPI-2 |
| Gene |
UniProtKB-ID:
WIPI2_HUMAN,
A0A024R823_HUMAN
UniprotKB:
Q9Y4P8,
A0A024R823
UniParc:
UPI00006688D2,
UPI0000073E34,
UPI00005B2EFF,
UPI00005B2F00,
UPI0000071F0D,
UPI00001D8A60
EMBL:
AY691426,
CR533530,
AL080155,
BC007596,
AC093376,
BC021068,
BC021200,
AK024279,
AF151808,
CH471144,
AY691425,
BC004116
Ensembl:
ENSG00000157954
KO:
hsa:26100
|
| Nucleutide sequences |
EMBL-CDS:
CAB45746.1,
AAV80762.1,
AAH21200.1,
AAD34045.1,
AAH07596.1,
AAQ96865.1,
AAH04116.1,
CAG38561.1,
AAQ96867.1,
EAW87328.1,
BAG51284.1,
AAV80761.1,
AAQ96866.1,
EAW87326.1,
EAW87327.1
Gene_ORFName:
CGI-50,
hCG_95500
Ensembl_TRS:
ENST00000382384,
ENST00000288828,
ENST00000484262,
ENST00000404704,
ENST00000401525
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000288828,
ENSP00000384945,
ENSP00000429654,
ENSP00000371821,
ENSP00000385297
RefSeq:
NP_057087.2,
NP_001028691.1,
XP_006715748.1,
NP_001028692.1,
NP_056425.1,
NP_001265228.1,
NP_001028690.1,
XP_016867441.1
|
| Others |
UniRef100:
UniRef100_Q9Y4P8
UniRef90:
UniRef90_Q9Y4P8
UniRef50:
UniRef50_Q9Y4P8
UniGene:
Hs.122363
CCDS:
CCDS47533.1,
CCDS34593.1,
CCDS47531.1,
CCDS47532.1,
CCDS5339.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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