The protein interaction landscape of the human CMGC kinase group.
[No authors listed]
摘要
Cellular information processing via reversible protein phosphorylation requires tight control of the localization, activity, and substrate specificity of protein kinases, which to a large extent is accomplished by complex formation with other proteins. Despite their critical role in cellular regulation and pathogenesis, protein interaction information is available for only a subset of the 518 human protein kinases. Here we present a global proteomic analysis of complexes of the human CMGC kinase group. In addition to subgroup-specific functional enrichment and modularity, the identified 652 high-confidence kinase-protein interactions provide a specific biochemical context for many poorly studied CMGC kinases. Furthermore, the analysis revealed a kinase-kinase subnetwork and candidate substrates for CMGC kinases. Finally, the presented interaction proteome uncovered a large set of interactions with proteins genetically linked to a range of human diseases, including cancer, suggesting additional routes for analyzing the role of CMGC kinases in controlling human disease pathways.
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基因功能
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基因
MED6, PDCD6IP, FRAT1, TROAP, MED16, RWDD2B, HUWE1, EDIL3, ARPC1B, HIPK3, FRY, AKAP9, SUGP2, RASA4, CDK2, RBM7, CDK3, CDK4, PSME3, CDK5, FLOT1, DDX39A, CDK6, CDK7, HNRNPR, DCAF7, CDK8, SRRM1, CDK9, SF3B4, CDKN1A, AKAP8, CDKN1B, STUB1, CDKN1C, CDKN2A, PAK4, CDKN2B, ZNF267, CDKN2C, CDKN2D, NPM2, CACNG2, RBM14, HAX1, BAIAP2, PFDN6, EIF3M, SEC23B, ENOX2, MYBBP1A, CHERP, NOP56, UBD, MAB21L2, DRAP1, PRPF8, CDC42EP3, USP39, PTGES3, YME1L1, NUP50, HBS1L, AHCYL1, ZMYND11, ZNF460, CPSF4, TRAFD1, MAGED2, RNPS1, SUB1, SRSF8, AFG3L2, MSL3, STIP1, EBNA1BP2, SNRNP27, STON1, NUDT21, CPSF6, CHD2, SNRNP35, DIDO1, WDR5, KRR1, FOXN3, CLASRP, KPTN, WDR6, SUPT16H, CHEK2, AKAP11, EGLN2, MED8, GLCCI1, GABARAP, U2AF2, CHUK, EVI5L, CKS1B, CKS2, RPL39L, FTSJ3, SFXN2, CLU, CLK1, CLK2, CLK3, C16orf78, WDR81, SRSF12, CREBBP, CRHR1, NOL4L, CBLN4, RIMS4, DYNLL2, SREK1, ADPRH, MAPK14, FAM76B, CSNK2A1, CSNK2A2, CSNK2B, C18orf25, HIPK4, CTBP2, CLDN19, CTNNB1, OR6B3, CTSB, FAM117B, CSAG1, MARCH10, DDB1, DAW1, DDX5, DDX6, DHX8, DHX9, DHX15, LCA5, ASXL1, DHPS, DMBT1, DSC1, DSG1, DUSP6, DUSP8, DUSP9, DYRK1A, ECM1, EEF1A2, EEF2, EIF2S3, TRIM65, C4orf46, C9orf72, EP300, EPB41L1, EPHA3, HIPK1, ERBB2, ERCC2, ERCC3, ERCC5, ERN1, ESRRG, FANCD2, ACSL3, FAM124A, LRRN4CL, ALKBH3, ADGRG5, FOXK1, A2M, MAPK15, FGF12, FGFR1, FHL1, DNAJC8, ICK, ZNF510, FKBP3, FKBP5, SHANK2, SLC4A1AP, PDCD11, ACIN1, SNRNP200, RBM34, RRP1B, ERC1, ARHGAP26, SIPA1L3, CDK19, GPATCH8, RTF1, PASK, LARP4B, FLT1, OBSL1, LARP1, ICE1, AHCYL2, MED13L, FNTA, SIRT1, FNTB, CBX5, PHF3, NUP188, SCRIB, SKIV2L2, SRRM2, ZNF281, FOS, TNPO3, CDK20, CDC42EP4, GABARAPL1, FKBP8, IFIT5, PRPF6, FTH1, ABL1, RNF169, CCDC28A, GAPDH, SIPA1L1, CHTOP, PRPF31, RSL1D1, GNL3, SRPK3, PABPC1, NSG1, PDE7B, AFF4, RBMX, APOBEC3C, AMY2A, GOLGA2, LAMA1, WDR62, ODF3L2, HKR1, MKNK2, SETD2, MED4, DROSHA, GSK3A, GSK3B, GTF2E1, GTF2H1, GTF2H2, GTF2H3, GTF2H4, CPSF1, TRA2A, LINC00312, HMGB1, HNRNPA1, HNRNPC, HNRNPF, HNRNPH2, APC, PRMT1, APEX1, CCDC137, HNRNPCL1, APOD, IMPDH2, INSR, ARAF, JUN, JUP, KCNN2, KPNA1, KPNB1, KPNA2, YPEL2, AFF3, LAMC1, LBR, LIMK1, C11orf87, MED11, GTF2H5, LTF, ARNTL, SMAD4, MAGEB1, MAGOH, MAK, MAZ, MCM7, MDK, ASAH1, MLLT1, AFF1, MLLT3, MNAT1, MPP3, SPANXN4, MSN, MTR, HNRNPM, NCL, NDUFA4, NEB, DRG1, ATP1A1, SNU13, NOP2, CNOT2, CNOT3, NOVA1, ATP2B4, PCBP1, MED31, EXOSC1, RRP15, SDF4, DDX47, CDKL3, CDK16, CDK17, CDK18, FAM53C, RSRC1, ARL6IP4, YTHDF2, SFMBT1, NOP16, GSKIP, PHF7, PPHLN1, PDGFRA, TDP2, LARP7, MED15, NOP58, LUC7L2, PPIL1, NLK, PDPK1, LUC7L3, CDK12, STK26, PFDN1, PFDN2, PFDN4, PFDN5, PFKP, PFN1, CDK14, SERPINB10, PIGR, PIP, PKM, PKP2, CLIC5, CPSF2, PNN, POLB, POLR2B, POLR2E, GAR1, TAF7L, DGCR8, MED1, NSMCE4A, PPIA, MED18, WDR55, PPP1R2, ARGLU1, MED9, FAM90A1, RBM23, PPP2CB, PPP2R2A, LRRC1, MCOLN3, BRIX1, ZNF444, WDR33, PPP5C, NCBP3, NOP10, CNOT11, MED29, ZCCHC8, PRKAA1, PRPF40A, PRKACA, LUC7L, FAM222B, PRKAR1A, ENAH, NGLY1, MBNL3, VIMP, CAND1, NXT2, PRKG2, MAPK1, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK11, MAPK9, MAPK10, MAP2K3, MEPCE, AZGP1, MASP1, B2M, PSMA3, PSMA7, PSMB2, EXOSC5, DHX33, PSMB5, RSRP1, PSMC6, PSMD1, BACH1, PELI2, PELI1, PTBP1, CLK4, WDR18, PTK2, ESYT2, SIPA1L2, PTMA, SLAIN2, EP400, ZFP14, ABCD3, RBM25, MOK, RAF1, RANBP2, RANGAP1, RB1, RBBP4, RBBP6, RBL1, RBL2, GNB4, RBMS2, RCN1, RDX, RIT2, RIT1, RNF4, FASTKD5, ROCK1, RPL22, RPL41, RPS6KA2, RPS6KA3, RPS6KB2, MAPK12, SEC13, SEMG2, EPB41L4A, SRSF1, SRSF2, SRSF3, SRSF4, SRSF5, SRSF6, NOC3L, SRSF7, TRA2B, SUDS3, RBM15, MRPS11, MRPS6, SKI, SKP1, SKP2, CDK15, MARCKSL1, RSRC2, SPATS2, SNRNP70, SNRPA, SNRPB, SNRPC, SNRPD1, SON, SORL1, SPTAN1, SRI, SRPK1, SRPK2, STAU1, AURKA, CDKL5, AURKC, MED22, TCOF1, TEK, TLE3, TLE4, TOP1, TP53, TPD52, TRPS1, TTN, CDK11A, U2AF1, UBE2E2, VARS, VBP1, VDR, EZR, VRK1, YWHAB, CNBP, ZNF33A, ZNF146, ZNF223, CACNB1, ALMS1, MAPKAPK3, USP7, KCNAB1, DDX50, DDX54, CCDC86, TNIP2, C1orf35, BAG6, DDX39B, NELFE, TFEB, EPS8L3, NKAP, RNF219, CEP97, OCEL1, ICE2, ZMAT4, FAM57A, C11orf63, LPCAT1, ATAT1, FAM192A, DBF4B, BRD3, WDCP, TRABD, MED28, FAM117A, FIP1L1, CAMK2D, VANGL1, CABLES2, ZRSR2, USP11, USP9X, SMC1A, UBL4A, AXIN1, AXIN2, SF3B5, CCM2, AMMECR1L, YPEL3, ATAD3B, CCDC8, NSRP1, KAT8, SETD3, MED10, NTPCR, LLPH, NCK2, DYRK3, LZTS2, DYRK2, NEURL4, KIAA1841, MRPL43, MAP1LC3A, LCE3D, HIRIP3, PHF5A, ZNF514, FAM222A, PRPF38A, YBX3, CAMK1, DCLK3, TNKS1BP1, MAPKAPK5, CDK10, MKNK1, CASK, PRKRA, CDK13, DYNLL1, EIF3I, SRSF9, PABPC4, TNFRSF10C, DYRK4, CDKL1, IQGAP1, CDK5R1, PRPF4B, CCNA2, CACNA1H, CCNB1, CCNC, HERC2, SNURF, CCND2, CCND3, NAV1, PPP1R3F, CCNE1, RPS6KA4, CDKL2, ZNF30, TAF1B, CCNH, CCDC97, MED30, CCNT1, CCNT2, EIF1AY, PKMYT1, SART1, TRIM41, PRPF4, CCNB2, CCNE2, DYRK1B, FIBP, YTHDC1, CABLES1, DDX21, C11orf52, MAPKAPK2, MED14, HMGN3, TCEAL1, EFTUD2, SDR42E1, PPIG, CIAO1, ZRANB2, SNRNP40, MED21, ARHGAP12, TJP2, DDX23, MED23, MED17, MED27, MED7, HOMER3, MED20, TECR, H2AFY, RBM39, ZNF516, CCP110, LZTS3, TMEM94, BCLAF1, EIF4A3, KIAA0232, CUL7, RB1CC1, CDK1, C2CD5, CEP350, MED24, DDX46, UBAP2L, RBM8A, THRAP3, MED12, MED13
原始数据
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文献解读
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