| Type | Description |
|---|---|
| Definition | WD repeat domain 62 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-07 10:45:00 | relative WDR62 mRNA expression was not statistically different in differentiated thyroid carcinoma tissues and goiter tissues | 30884127 |
| 2019-08-31 10:17:00 | The expression levels of miR223 were significantly decreased in clinical bladder cancer (BC) specimens. The restoration of miR223 expression significantly inhibited tumor aggressiveness and induced apoptosis in BC cells. Direct binding between oncogenic WDR62 and miR223 was confirmed by luciferase assay. The knockdown of WDR62 significantly inhibited tumor aggressiveness and induced the apoptosis of BC cells. | 30942440 |
| 2019-07-13 11:14:00 | Study in mutant mice and human cerebral organoids showed that WDR62 deletion resulted in a reduction in the size of mouse brains and organoids due to the disruption of neural progenitor cells. WDR62 interacts with and promotes CEP170 localization to the basal body of primary cilium, where CEP170 recruits KIF2A to disassemble cilium. | 31197141 |
| 2019-06-23 00:15:00 | Haplotype analysis showed genetic relatedness between the families of the patients. Our findings expand the spectrum of mutations randomly distributed in the WDR62 gene. A review is also provided of the brain malformations described in WDR62 mutations in association with congenital microcephaly | 30706430 |
| 2019-05-11 13:04:00 | WDR62 coordinates the TNFalpha receptor signaling pathway to JNK activation through association with multiple kinases and the adaptor protein TRAF2. | 30091641 |
| Type | IDs |
|---|---|
| Synonymous | C19orf14, MCPH2 |
| Gene |
UniProtKB-ID:
WDR62_HUMAN
UniprotKB:
O43379
UniParc:
UPI000022A7E9,
UPI00001609EC,
UPI0000DBEE90,
UPI0000440991
EMBL:
AL133651,
AC004144,
BC058939,
AD000813,
AK090617,
BX647726,
BC017261
Ensembl:
ENSG00000075702
KO:
hsa:284403
|
| Nucleutide sequences |
EMBL-CDS:
CAH56390.1,
BAC03488.1,
CAH56191.1,
AAC27979.1,
AAH17261.1
Ensembl_TRS:
ENST00000401500,
ENST00000270301,
ENST00000587391
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000465525,
ENSP00000270301,
ENSP00000384792
RefSeq:
XP_011525140.1,
NP_001077430.1,
XP_011525141.1,
XP_011525142.1,
XP_011525145.1,
XP_005258866.1,
XP_016882154.1,
XP_011525139.1,
XP_011525144.1,
NP_775907.4,
XP_011525146.1,
XP_011525143.1
|
| Others |
UniRef100:
UniRef100_O43379
UniRef90:
UniRef90_O43379
UniRef50:
UniRef50_O43379
UniGene:
Hs.116244
CCDS:
CCDS46059.1,
CCDS33001.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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