| Type | Description |
|---|---|
| Definition | MLLT1 super elongation complex subunit |
| Date | Results | Publications |
|---|---|---|
| 2020-08-01 10:50:00 | Our findings show that the efficiency of MLL-ENL-driven AML initiation changes through the course of pre- and postnatal development, and developmental programs can be manipulated to impede transformation. | 31405949 |
| 2018-10-06 12:17:00 | This review will not only provide a fundamental understanding of the structure and function of ENL and update on the roles of ENL in acute myeloid leukemia, but also the development of new therapeutic strategies | 30066088 |
| 2017-07-15 11:40:00 | data identify ENL as a histone acetylation reader that regulates oncogenic transcriptional programs in acute myeloid leukaemia, and suggest that displacement of ENL from chromatin may be a promising epigenetic therapy, alone or in combination with BET inhibitors, for aggressive leukaemia | 28241141 |
| 2017-05-08 14:24:00 | MLL-ENL dysregulated the proliferative and repopulating capacity of hematopoietic stem cells. | 25456127 |
| 2016-07-02 10:26:00 | Recurrent mutations within Wilms tumours involve the highly conserved YEATS domain of MLLT1. | 26635203 |
| Type | IDs |
|---|---|
| Synonymous | ENL, LTG19, YEATS1 |
| Gene |
UniProtKB-ID:
ENL_HUMAN
UniprotKB:
Q03111
UniParc:
UPI000006F7B3
EMBL:
L04285,
D14539
Ensembl:
ENSG00000130382
KO:
hsa:4298
|
| Nucleutide sequences |
EMBL-CDS:
AAA58457.1,
BAA03406.1
Ensembl_TRS:
ENST00000252674
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000252674
RefSeq:
NP_005925.2,
XP_011526323.1,
XP_011526324.1,
XP_011526325.1,
XP_016882308.1
|
| Others |
UniRef100:
UniRef100_Q03111
UniRef90:
UniRef90_Q03111
UniRef50:
UniRef50_Q03111
UniGene:
Hs.10095
CCDS:
CCDS12160.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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