| Type | Description |
|---|---|
| Definition | kaptin, actin binding protein |
| Date | Results | Publications |
|---|---|---|
| 2017-08-19 10:14:00 | identification of a protein complex (KICSTOR) that is composed of four proteins, KPTN, ITFG2, C12orf66 and SZT2, and that is required for amino acid or glucose deprivation to inhibit mTORC1 in cultured human cells | 28199306 |
| 2014-03-01 10:09:00 | We have demonstrated that mutations in KPTN, encoding kaptin, cause a syndrome typified by macrocephaly, neurodevelopmental delay, and seizures. | 24239382 |
| Type | IDs |
|---|---|
| Synonymous | 2E4, MRT41 |
| Gene |
UniProtKB-ID:
KPTN_HUMAN,
A0A384NLB4_HUMAN
UniprotKB:
Q9Y664,
A0A384NLB4
UniParc:
UPI00017A7948,
UPI000007002E
EMBL:
AK023996,
CH471126,
BC009249,
AC073548,
AF243529,
GQ901026,
AK298672,
AF105369
Ensembl:
ENSG00000118162
KO:
hsa:11133
|
| Nucleutide sequences |
EMBL-CDS:
AAH09249.1,
AAF98790.1,
BAG51248.1,
EAW57487.1,
BAG60838.1,
AAD39358.1,
ADO22543.1
Ensembl_TRS:
ENST00000338134
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000337850
RefSeq:
NP_001278225.1,
XP_016881715.1,
XP_016881717.1,
XP_024307101.1,
NP_008990.2,
XP_016881718.1,
XP_016881716.1
|
| Others |
UniRef100:
UniRef100_Q9Y664
UniRef90:
UniRef90_Q9Y664
UniRef50:
UniRef50_Q9Y664
UniGene:
Hs.25441
CCDS:
CCDS42583.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32694731 |
Nat Metab Michael Aregger , Keith A Lawson , Maximillian Billmann , Michael Costanzo , Amy H Y Tong , Katherine Chan , Mahfuzur Rahman , Kevin R Brown , Catherine Ross , Matej Usaj , Lucy Nedyalkova , Olga Sizova , Andrea Habsid , Judy Pawling , Zhen-Yuan Lin , Hala Abdouni , Cassandra J Wong , Alexander Weiss , Patricia Mero , James W Dennis , Anne-Claude Gingras , Chad L Myers , Brenda J Andrews , Charles Boone , Jason Moffat |
2020-06-01 | - |
| 28514442 |
Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper |
2017-05-25 | - |
| 28199306 |
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature Rachel L Wolfson , Lynne Chantranupong , Gregory A Wyant , Xin Gu , Jose M Orozco , Kuang Shen , Kendall J Condon , Sabrina Petri , Jibril Kedir , Sonia M Scaria , Monther Abu-Remaileh , Wayne N Frankel , David M Sabatini |
2017-03-16 | - |
| 26186194 |
The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell Edward L Huttlin , Lily Ting , Raphael J Bruckner , Fana Gebreab , Melanie P Gygi , John Szpyt , Stanley Tam , Gabriela Zarraga , Greg Colby , Kurt Baltier , Rui Dong , Virginia Guarani , Laura Pontano Vaites , Alban Ordureau , Ramin Rad , Brian K Erickson , Martin Wühr , Joel Chick , Bo Zhai , Deepak Kolippakkam , Julian Mintseris , Robert A Obar , Tim Harris , Spyros Artavanis-Tsakonas , Mathew E Sowa , Pietro De Camilli , Joao A Paulo , J Wade Harper , Steven P Gygi |
2015-07-16 | - |
| 24239382 |
Mutations in KPTN cause macrocephaly, neurodevelopmental delay, and seizures. Am. J. Hum. Genet. Emma L Baple , Reza Maroofian , Barry A Chioza , Maryam Izadi , Harold E Cross , Saeed Al-Turki , Katy Barwick , Anna Skrzypiec , Robert Pawlak , Karin Wagner , Roselyn Coblentz , Tala Zainy , Michael A Patton , Sahar Mansour , Phillip Rich , Britta Qualmann , Matt E Hurles , Michael M Kessels , Andrew H Crosby |
2014-01-02 | - |
| 23602568 |
The protein interaction landscape of the human CMGC kinase group. Cell Rep Markku Varjosalo , Salla Keskitalo , Audrey Van Drogen , Helka Nurkkala , Anton Vichalkovski , Ruedi Aebersold , Matthias Gstaiger |
2013-04-25 |
MED6,
PDCD6IP,
FRAT1,
TROAP,
MED16,
RWDD2B,
HUWE1,
EDIL3,
ARPC1B,
HIPK3,
FRY,
AKAP9,
SUGP2,
RASA4,
CDK2,
RBM7,
CDK3,
CDK4,
PSME3,
CDK5,
FLOT1,
DDX39A,
CDK6,
CDK7,
HNRNPR,
DCAF7,
CDK8,
SRRM1,
CDK9,
SF3B4,
CDKN1A,
AKAP8,
CDKN1B,
STUB1,
CDKN1C,
CDKN2A,
PAK4,
CDKN2B,
ZNF267,
CDKN2C,
CDKN2D,
NPM2,
CACNG2,
RBM14,
HAX1,
BAIAP2,
PFDN6,
EIF3M,
SEC23B,
ENOX2,
MYBBP1A,
CHERP,
NOP56,
UBD,
MAB21L2,
DRAP1,
PRPF8,
CDC42EP3,
USP39,
PTGES3,
YME1L1,
NUP50,
HBS1L,
AHCYL1,
ZMYND11,
ZNF460,
CPSF4,
TRAFD1,
MAGED2,
RNPS1,
SUB1,
SRSF8,
AFG3L2,
MSL3,
STIP1,
EBNA1BP2,
SNRNP27,
STON1,
NUDT21,
CPSF6,
CHD2,
SNRNP35,
DIDO1,
WDR5,
KRR1,
FOXN3,
CLASRP,
KPTN,
WDR6,
SUPT16H,
CHEK2,
AKAP11,
EGLN2,
MED8,
GLCCI1,
GABARAP,
U2AF2,
CHUK,
EVI5L
|
| 21832049 |
J Biol Chem Judit Oláh , Orsolya Vincze , Dezsõ Virók , Dóra Simon , Zsolt Bozsó , Natália Tõkési , István Horváth , Emma Hlavanda , János Kovács , Anna Magyar , Mária Szũcs , Ferenc Orosz , Botond Penke , Judit Ovádi |
2011-09-30 | - |
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 17353931 |
Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol. Syst. Biol. Rob M Ewing , Peter Chu , Fred Elisma , Hongyan Li , Paul Taylor , Shane Climie , Linda McBroom-Cerajewski , Mark D Robinson , Liam O'Connor , Michael Li , Rod Taylor , Moyez Dharsee , Yuen Ho , Adrian Heilbut , Lynda Moore , Shudong Zhang , Olga Ornatsky , Yury V Bukhman , Martin Ethier , Yinglun Sheng , Julian Vasilescu , Mohamed Abu-Farha , Jean-Philippe Lambert , Henry S Duewel , Ian I Stewart , Bonnie Kuehl , Kelly Hogue , Karen Colwill , Katharine Gladwish , Brenda Muskat , Robert Kinach , Sally-Lin Adams , Michael F Moran , Gregg B Morin , Thodoros Topaloglou , Daniel Figeys |
2007-01-01 |
PDCD6IP,
CHAF1A,
PARP3,
RANBP9,
SMC4,
UBA2,
SAE1,
ARPC5,
ARPC4,
ARPC3,
ARPC1B,
ACTR3,
ACTR2,
ARPC2,
RAD50,
RASGRP1,
LRPPRC,
PDIA6,
G3BP1,
TRIM28,
CDK2,
CDK4,
PSME3,
CDK6,
PSMD14,
HNRNPR,
SRRM1,
DENND4A,
SF3B4,
LOC400927-CSNK1E,
SAP18,
SMNDC1,
BCAS2,
EIF1B,
SF3A1,
CDKN2A,
BCKDK,
PAK4,
CDKN2C,
CDO1,
YAP1,
CD2BP2,
UBAC1,
MCRS1,
BAIAP2,
PFDN6,
EIF3M,
SYNCRIP,
STK25,
MYBBP1A,
HYOU1,
NOP56,
SSSCA1,
GLRX3,
ARPC1A,
SPTLC1,
SORBS1,
SMC2,
PRPF8,
AHSA1,
PAICS,
MYL12A,
ATP5L,
NPRL2,
IGF2BP1,
IGF2BP3,
IGF2BP2,
PMVK,
PNMA2,
USP39,
AP4B1,
POLQ,
CFL1,
NUDC,
PTGES3,
MAP3K2,
GIPC1,
SRSF10,
NEK6,
NCKAP1,
IQGAP2,
MTHFD2,
SDCCAG3,
CLPX,
RUVBL2,
PGRMC1,
RAB10,
MALT1,
RNPS1,
MORF4L1,
KDELR1,
SF3A3,
SERINC3,
STIP1,
ACOT2,
EBNA1BP2,
YWHAQ,
GCN1,
SF3B2
|
| 16344560 |
Genome Res. Kouichi Kimura , Ai Wakamatsu , Yutaka Suzuki , Toshio Ota , Tetsuo Nishikawa , Riu Yamashita , Jun-ichi Yamamoto , Mitsuo Sekine , Katsuki Tsuritani , Hiroyuki Wakaguri , Shizuko Ishii , Tomoyasu Sugiyama , Kaoru Saito , Yuko Isono , Ryotaro Irie , Norihiro Kushida , Takahiro Yoneyama , Rie Otsuka , Katsuhiro Kanda , Takahide Yokoi , Hiroshi Kondo , Masako Wagatsuma , Katsuji Murakawa , Shinichi Ishida , Tadashi Ishibashi , Asako Takahashi-Fujii , Tomoo Tanase , Keiichi Nagai , Hisashi Kikuchi , Kenta Nakai , Takao Isogai , Sumio Sugano |
2006-01-01 |
Nefm,
MED6,
CDH2,
PDZK1P1,
DDTL,
ABI1,
GNPDA1,
GTF2IP4,
ZSCAN30,
SRA1,
TMEM170B,
HOTAIR,
FAM86JP,
LOC100126784,
C8orf88,
LOC100128006,
RAB28P5,
MYHAS,
CDC42P3,
LOC100128979,
LOC100128993,
KTN1-AS1,
LOC100129083,
LOC100129204,
TOPORS-AS1,
LINC00484,
ZNF37BP,
FAM47E,
MRVI1-AS1,
ZNF737,
LOC100130075,
MAPT-IT1,
MIR124-2HG,
LINC00861,
LOC100130238,
LOC100130357,
PARD6G-AS1,
LOC100130547,
NFYC-AS1,
EFCAB10,
LOC100130798,
SBK3,
LOC100130849,
LOC100130872,
LOC100130880,
LOC100130987,
LOC100131047,
LINC01135,
CKMT2-AS1,
ZBTB20-AS1,
WDR86-AS1,
CCDC183-AS1,
SNAP25-AS1,
NEMP2,
ZNF503-AS2,
MIR181A1HG,
DBIL5P,
HDAC6,
MZF1-AS1,
ARMCX4,
LINC00271,
ZNF717,
LOC100132057,
LOC100132111,
CALML3-AS1,
NDUFA6-AS1,
FRG1HP,
FCGR1CP,
GXYLT1P3,
GOLGA8F,
DCAF13P3,
IPO5P1,
MSC-AS1,
SMIM9,
FAM66A,
CD24,
UXT-AS1,
JHDM1D-AS1,
UBE2Q2P2,
TEN1,
JMJD7,
PLA2G4B,
LINC00930,
PDCD6IP,
HECTD2-AS1,
ZFHX4-AS1,
FAR2P2,
LOC100233156,
PCED1B-AS1,
PIGK,
LOC100270746,
LOC100270804,
LINC00940,
ERVV-2,
MEF2B,
ZNRF2P2,
NFE2L3P2,
LINC00894,
BCDIN3D-AS1
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员