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10270 AKAP8

10270

AKAP8

A-kinase anchoring protein 8

protein-coding

Homo sapiens

基因描述

Type Description
Definition A-kinase anchoring protein 8

研究结论

Date Results Publications
2021-02-13 13:26:00 A-Kinase Anchoring Proteins Diminish TGF-beta1/Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition. 32028718
2020-10-31 13:17:00 Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis. 32719551
2020-04-25 12:33:00 It consists of AKAP95, and PDE4D5 and show that it forms a functional cyclic AMP (cAMP) signaling microdomain. 30982750
2020-04-18 10:18:00 Identification of A-Kinase Anchor Protein (AKAP8) as a splicing regulatory factor that impedes EMT and breast cancer metastasis. AKAP8 not only is capable of inhibiting splicing activity of the EMT-promoting splicing regulator hnRNPM through protein-protein interaction, it also directly binds to RNA and alters splicing outcomes. Genome-wide analysis shows that AKAP8 promotes an epithelial cell state splicing program. 31980632
2019-09-14 12:32:00 The results of the present study demonstrate a crucial role for AKAP95 in CYP19A1 expression and oestrogen synthesis in humans luteinized granulosa cells, which implies that AKAP95 may be involved in the pathogenesis of polycystic ovary syndrome. 29397057

名称对应

Type IDs
Synonymous AKAP 95, AKAP-8, AKAP-95, AKAP95
Gene
UniProtKB-ID: AKAP8_HUMAN
UniprotKB: O43823
UniParc: UPI000012575C
EMBL: AC005785, Y11997
Ensembl: ENSG00000105127
KO: hsa:10270
Nucleutide sequences
EMBL-CDS: AAC62838.1, CAA72722.1
Ensembl_TRS: ENST00000269701
Protein sequencees
Ensembl_PRO: ENSP00000269701
RefSeq: NP_005849.1
Others
UniRef100: UniRef100_O43823
UniRef90: UniRef90_O43823
UniRef50: UniRef50_O43823
UniGene: Hs.594496
CCDS: CCDS12329.1

全选

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研究热度

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