| Type | Description |
|---|---|
| Definition | dual specificity tyrosine phosphorylation regulated kinase 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 12:57:00 | Impairment of DYRK2 by DNMT1mediated transcription augments carcinogenesis in human colorectal cancer. | 32236621 |
| 2020-06-20 12:56:00 | DYRK2 is strongly activated in normal or early-stage tumor cells, where they effectively degrade Snail through betaTrCP-mediated ubiquitination, thus suppressing epithelial-mesenchymal transition. | 31209060 |
| 2020-06-20 11:17:00 | Especially in tumor cells, accumulating studies have revealed the molecular mechanisms of DYRK2 from the aspect of apoptosis, proliferation, EMT, and stem- ness. Considering in vitro and xenograft studies as well as down-regulation of DYRK2 in tumor specimens, DYRK2 is an important candidate for tumor suppressor. [review] | 31505048 |
| 2020-05-30 12:10:00 | DYRK2 phosphorylates NDEL1 S336 to prime the phosphorylation of NDEL1 S332 by GSK3beta. The data suggest the NDEL1 phosphorylation at S336/S332 by the TARA-DYRK2-GSK3beta complex as a novel regulatory mechanism underlying neuronal morphogenesis. | 31815665 |
| 2020-02-15 11:00:00 | found that liver cancer patients with low DYRK2 expression had a significantly shorter overall survival | 30851422 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
DYRK2_HUMAN
UniprotKB:
Q92630
UniParc:
UPI000006E92B,
UPI0000000C6D
EMBL:
BC006375,
Y13493,
BC005809,
Y09216,
CH471054,
AK313937
Ensembl:
ENSG00000127334
KO:
hsa:8445
|
| Nucleutide sequences |
EMBL-CDS:
EAW97176.1,
CAA73885.1,
BAG36656.1,
CAA70418.1,
AAH06375.1,
AAH05809.1
Ensembl_TRS:
ENST00000393555,
ENST00000344096
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000342105,
ENSP00000377186
RefSeq:
NP_003574.1,
NP_006473.2,
XP_016875521.1
|
| Others |
UniRef100:
UniRef100_Q92630
UniRef90:
UniRef90_Q92630
UniRef50:
UniRef50_Q92630
UniGene:
Hs.173135
CCDS:
CCDS8979.1,
CCDS8978.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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