| Type | Description |
|---|---|
| Definition | RAS p21 protein activator 4 |
| Date | Results | Publications |
|---|---|---|
| 2015-05-16 12:04:00 | RASA4 isoform 2 promoter methylation correlated with clinical parameters predicting poor prognosis (older age, elevated fetal hemoglobin), with higher risk of relapse after hematopoietic stem cell transplantation, and with PTPN11 mutation. | 25147919 |
| 2011-08-06 10:25:00 | Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities | 21460216 |
| 2010-01-21 00:00:00 | CAPRI seems to low-pass filter the Ca2+ signal, converting different intensities of stimulation into different durations of Ras activity. | 16009725 |
| 2001-09-25 10:47:00 | CAPRI (Ca2+-promoted Ras inactivator) a Ca2+-dependent Ras GTPase-activating protein (Ras GAP). Switches off the Ras-MAPK pathway following G protein-coupled receptor stimulated intracellular Ca2+ elevation that recruits CAPRI to the plasma membrane. | 11448776 |
| Type | IDs |
|---|---|
| Synonymous | CAPRI, GAPL |
| Gene |
UniProtKB-ID:
RASL2_HUMAN
UniprotKB:
O43374
UniParc:
UPI0001AE70B9,
UPI00001BBB72
EMBL:
AC093668,
AC105052,
BC113663,
AB011110,
AK026441,
AC004084,
AY029206
Ensembl:
ENSG00000105808
KO:
hsa:10156
|
| Nucleutide sequences |
EMBL-CDS:
AAK31582.1,
AAI13664.1,
AAB97935.2,
AAP22345.1,
BAA25464.2
Ensembl_TRS:
ENST00000449970,
ENST00000262940
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000262940,
ENSP00000412876
RefSeq:
XP_016867151.1,
NP_001073346.2,
NP_008920.5,
XP_011514025.1,
XP_016867150.1
|
| Others |
UniRef100:
UniRef100_O43374
UniRef90:
UniRef90_O43374
UniRef50:
UniRef50_O43374
UniGene:
Hs.530089,
Hs.656696
CCDS:
CCDS47674.1,
CCDS5725.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 30655611 |
WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation. Nat Commun Woo-Jeong Jeong , Jong-Chan Park , Woo-Shin Kim , Eun Ji Ro , Soung Hoo Jeon , Sang-Kyu Lee , Young Nyun Park , Do Sik Min , Kang-Yell Choi |
2019-01-17 | - |
| 25921289 |
Sci Signal Kristina B Emdal , Anna-Kathrine Pedersen , Dorte B Bekker-Jensen , Kalliopi P Tsafou , Heiko Horn , Sven Lindner , Johannes H Schulte , Angelika Eggert , Lars J Jensen , Chiara Francavilla , Jesper V Olsen |
2015-04-28 | - |
| 25147919 |
RASA4 undergoes DNA hypermethylation in resistant juvenile myelomonocytic leukemia. Epigenetics Anna R Poetsch , Daniel B Lipka , Tania Witte , Rainer Claus , Peter Nöllke , Manuela Zucknick , Christiane Olk-Batz , Silvia Fluhr , Michael Dworzak , Barbara De Moerloose , Jan Starý , Marco Zecca , Henrik Hasle , Markus Schmugge , Marry M van den Heuvel-Eibrink , Franco Locatelli , Charlotte M Niemeyer , Christian Flotho , Christoph Plass |
2014-09-01 |
RASA4
|
| 23602568 |
The protein interaction landscape of the human CMGC kinase group. Cell Rep Markku Varjosalo , Salla Keskitalo , Audrey Van Drogen , Helka Nurkkala , Anton Vichalkovski , Ruedi Aebersold , Matthias Gstaiger |
2013-04-25 |
MED6,
PDCD6IP,
FRAT1,
TROAP,
MED16,
RWDD2B,
HUWE1,
EDIL3,
ARPC1B,
HIPK3,
FRY,
AKAP9,
SUGP2,
RASA4,
CDK2,
RBM7,
CDK3,
CDK4,
PSME3,
CDK5,
FLOT1,
DDX39A,
CDK6,
CDK7,
HNRNPR,
DCAF7,
CDK8,
SRRM1,
CDK9,
SF3B4,
CDKN1A,
AKAP8,
CDKN1B,
STUB1,
CDKN1C,
CDKN2A,
PAK4,
CDKN2B,
ZNF267,
CDKN2C,
CDKN2D,
NPM2,
CACNG2,
RBM14,
HAX1,
BAIAP2,
PFDN6,
EIF3M,
SEC23B,
ENOX2,
MYBBP1A,
CHERP,
NOP56,
UBD,
MAB21L2,
DRAP1,
PRPF8,
CDC42EP3,
USP39,
PTGES3,
YME1L1,
NUP50,
HBS1L,
AHCYL1,
ZMYND11,
ZNF460,
CPSF4,
TRAFD1,
MAGED2,
RNPS1,
SUB1,
SRSF8,
AFG3L2,
MSL3,
STIP1,
EBNA1BP2,
SNRNP27,
STON1,
NUDT21,
CPSF6,
CHD2,
SNRNP35,
DIDO1,
WDR5,
KRR1,
FOXN3,
CLASRP,
KPTN,
WDR6,
SUPT16H,
CHEK2,
AKAP11,
EGLN2,
MED8,
GLCCI1,
GABARAP,
U2AF2,
CHUK,
EVI5L
|
| 21460216 |
J Biol Chem Yanfeng Dai , Simon A Walker , Edwin de Vet , Simon Cook , Heidi C E Welch , Peter J Lockyer |
2011-06-03 | - |
| 18320585 |
Proteins Steffen Pahlich , Rouzanna P Zakaryan , Heinz Gehring |
2008-09-01 |
EWSR1,
PRMT8
|
| 16344560 |
Genome Res. Kouichi Kimura , Ai Wakamatsu , Yutaka Suzuki , Toshio Ota , Tetsuo Nishikawa , Riu Yamashita , Jun-ichi Yamamoto , Mitsuo Sekine , Katsuki Tsuritani , Hiroyuki Wakaguri , Shizuko Ishii , Tomoyasu Sugiyama , Kaoru Saito , Yuko Isono , Ryotaro Irie , Norihiro Kushida , Takahiro Yoneyama , Rie Otsuka , Katsuhiro Kanda , Takahide Yokoi , Hiroshi Kondo , Masako Wagatsuma , Katsuji Murakawa , Shinichi Ishida , Tadashi Ishibashi , Asako Takahashi-Fujii , Tomoo Tanase , Keiichi Nagai , Hisashi Kikuchi , Kenta Nakai , Takao Isogai , Sumio Sugano |
2006-01-01 |
Nefm,
MED6,
CDH2,
PDZK1P1,
DDTL,
ABI1,
GNPDA1,
GTF2IP4,
ZSCAN30,
SRA1,
TMEM170B,
HOTAIR,
FAM86JP,
LOC100126784,
C8orf88,
LOC100128006,
RAB28P5,
MYHAS,
CDC42P3,
LOC100128979,
LOC100128993,
KTN1-AS1,
LOC100129083,
LOC100129204,
TOPORS-AS1,
LINC00484,
ZNF37BP,
FAM47E,
MRVI1-AS1,
ZNF737,
LOC100130075,
MAPT-IT1,
MIR124-2HG,
LINC00861,
LOC100130238,
LOC100130357,
PARD6G-AS1,
LOC100130547,
NFYC-AS1,
EFCAB10,
LOC100130798,
SBK3,
LOC100130849,
LOC100130872,
LOC100130880,
LOC100130987,
LOC100131047,
LINC01135,
CKMT2-AS1,
ZBTB20-AS1,
WDR86-AS1,
CCDC183-AS1,
SNAP25-AS1,
NEMP2,
ZNF503-AS2,
MIR181A1HG,
DBIL5P,
HDAC6,
MZF1-AS1,
ARMCX4,
LINC00271,
ZNF717,
LOC100132057,
LOC100132111,
CALML3-AS1,
NDUFA6-AS1,
FRG1HP,
FCGR1CP,
GXYLT1P3,
GOLGA8F,
DCAF13P3,
IPO5P1,
MSC-AS1,
SMIM9,
FAM66A,
CD24,
UXT-AS1,
JHDM1D-AS1,
UBE2Q2P2,
TEN1,
JMJD7,
PLA2G4B,
LINC00930,
PDCD6IP,
HECTD2-AS1,
ZFHX4-AS1,
FAR2P2,
LOC100233156,
PCED1B-AS1,
PIGK,
LOC100270746,
LOC100270804,
LINC00940,
ERVV-2,
MEF2B,
ZNRF2P2,
NFE2L3P2,
LINC00894,
BCDIN3D-AS1
|
| 16169070 |
A human protein-protein interaction network: a resource for annotating the proteome. Cell Ulrich Stelzl , Uwe Worm , Maciej Lalowski , Christian Haenig , Felix H Brembeck , Heike Goehler , Martin Stroedicke , Martina Zenkner , Anke Schoenherr , Susanne Koeppen , Jan Timm , Sascha Mintzlaff , Claudia Abraham , Nicole Bock , Silvia Kietzmann , Astrid Goedde , Engin Toksöz , Anja Droege , Sylvia Krobitsch , Bernhard Korn , Walter Birchmeier , Hans Lehrach , Erich E Wanker |
2005-09-23 |
Eif4a2,
Tmsb4x,
Supt5,
Trp53,
Tuba1a,
Ppp2r2d,
Ilf2,
Fam101a,
Tubb2b,
Cggbp1,
Sh3d21,
Rab11b,
Dnaja2,
psmd14,
SRA1,
HDAC5,
PDCD6IP,
TOM1L1,
SH2D3C,
UBA2,
DNM1L,
COX17,
SCAMP2,
RWDD2B,
DPP3,
SNUPN,
TSSC4,
PDCD7,
CDH10,
PQBP1,
ARPC4,
ARPC3,
ACTR1B,
TOB1,
TRIM28,
RASA4,
PDZK1IP1,
SERF2,
RBM5,
TNK2,
TXNDC9,
CDK4,
PSME3,
MPHOSPH6,
NUTF2,
PATJ,
EIF1,
FLOT1,
PLIN3,
RASGRP2,
HNRNPR,
MRPS31,
GLYAT,
CDKN1A,
CDK2AP2,
RAMP3,
CDKN1B,
STUB1,
EFS,
SAP18,
PAK4,
DLEU1,
CDKN2B,
APBB3,
CDKN2C,
TFG,
NPM3,
HMG20B,
TUBB3,
TUBB4B,
CORO2B,
NDRG1,
MYL9,
RACK1,
NDC80,
WFDC2,
PRMT5,
ARIH2,
EMG1,
TIMM17A,
PPIE,
HAX1,
BAIAP2,
TADA3,
ATP5H,
EIF3M,
CEACAM5,
LRRC41,
VTI1B,
UNC13B,
DEAF1,
KAT5,
GLRX3,
DCTN2,
LAMTOR5,
PROCR,
AGR2,
CXCL13,
RABAC1
|
| 16009725 |
J. Cell Biol. Qing Liu , Simon A Walker , Dingcheng Gao , James A Taylor , Yan-Feng Dai , Rebecca S Arkell , Martin D Bootman , H Llewelyn Roderick , Peter J Cullen , Peter J Lockyer |
2005-07-18 | - |
| 15489334 |
Genome Res. Daniela S Gerhard , Lukas Wagner , Elise A Feingold , Carolyn M Shenmen , Lynette H Grouse , Greg Schuler , Steven L Klein , Susan Old , Rebekah Rasooly , Peter Good , Mark Guyer , Allison M Peck , Jeffery G Derge , David Lipman , Francis S Collins , Wonhee Jang , Steven Sherry , Mike Feolo , Leonie Misquitta , Eduardo Lee , Kirill Rotmistrovsky , Susan F Greenhut , Carl F Schaefer , Kenneth Buetow , Tom I Bonner , David Haussler , Jim Kent , Mark Kiekhaus , Terry Furey , Michael Brent , Christa Prange , Kirsten Schreiber , Nicole Shapiro , Narayan K Bhat , Ralph F Hopkins , Florence Hsie , Tom Driscoll , M Bento Soares , Tom L Casavant , Todd E Scheetz , Michael J Brown-stein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Yulan Piao , Dawood B Dudekula , Minoru S H Ko , Koichi Kawakami , Yutaka Suzuki , Sumio Sugano , C E Gruber , M R Smith , Blake Simmons , Troy Moore , Richard Waterman , Stephen L Johnson , Yijun Ruan , Chia Lin Wei , S Mathavan , Preethi H Gunaratne , Jiaqian Wu , Angela M Garcia , Stephen W Hulyk , Edwin Fuh , Ye Yuan , Anna Sneed , Carla Kowis , Anne Hodgson , Donna M Muzny , John McPherson , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madari , Alice C Young , Keith D Wetherby , Steven J Granite , Peggy N Kwong , Charles P Brinkley , Russell L Pearson , Gerard G Bouffard , Robert W Blakesly , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Malachi Griffith , Obi L Griffith , Martin I Krzywinski , Nancy Liao , Ryan Morin , Ryan Morrin , Diana Palmquist , Anca S Petrescu , Ursula Skalska , Duane E Smailus , Jeff M Stott , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Robert A Holt , Agnes Baross , Marco A Marra , Sandra Clifton , Kathryn A Makowski , Stephanie Bosak , Joel Malek , MGC Project Team |
2004-10-01 |
Ldlrap1,
Dnajc3,
Rnaset2a,
Btnl1,
Isg15,
Cyp3a41b,
Ly6c2,
Ccl21b,
Eif3j2,
Mup18,
Lrrc19,
Rcc1,
1700047I17Rik2,
Pcsk9,
Adat3,
Tdrd7,
Sco2,
Gpr153,
Pafah2,
Gm44504,
H6pd,
Adprhl2,
Gpn2,
Rusc2,
Stx12,
Ppp1r8,
Smpdl3b,
Fam46b,
Bsdc1,
Slc44a1,
Zfand2a,
Rubcn,
Kifc1,
Pifo,
C030017K20Rik,
Cbarp,
Rpl5,
Micalcl,
Atg14,
Lrrc8c,
Noc4l,
Nsun5,
Psph,
Trrap,
Mapre3,
Ube3c,
Tbc1d14,
Hscb,
Tyw1,
Emilin1,
Rab28,
Pot1a,
Parp11,
Tada3,
Tra2a,
Brk1,
Fbxl14,
Phrf1,
Plekha1,
Gm21975,
Ric8a,
Mob2,
Prkd2,
Ccp110,
Vrk3,
Grwd1,
Nlrp6,
Trim68,
Psip1,
Spred3,
Faap24,
Ints4,
Rrp8,
Unc45a,
Igflr1,
Sf3b3,
D8Ertd738e,
Usb1,
Champ1,
Smim19,
Exoc8,
Gadd45gip1,
Phkb,
Dohh,
Fam192a,
Enkd1,
Taf5l,
Zdhhc7,
Snapc2,
Ak6,
Gpat4,
Dcun1d2,
Ankrd10,
Cog4,
Hinfp,
Lars2,
Xylb,
Imp3,
Cmtm7
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员