ICK - intestinal cell kinase-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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22858 ICK

基因描述

Type	Description
Definition	intestinal cell kinase

研究结论

Date	Results	Publications
2021-03-13 13:26:00	Functional Alterations in Ciliogenesis-Associated Kinase 1 (CILK1) that Result from Mutations Linked to Juvenile Myoclonic Epilepsy.	32178256
2021-02-02 13:27:00	Anterograde trafficking of ciliary MAP kinase-like ICK/CILK1 by the intraflagellar transport machinery is required for intraciliary retrograde protein trafficking.	32732286
2020-06-20 12:47:00	Previously known as intestinal cell kinase because it was cloned from that origin, CILK1 is now recognized as a widely expressed and highly conserved. Mutations in the human CILK1 gene have been associated with ciliopathies. Thus, CILK1 has a fundamental role in the function of the cilium. Several candidate substrates have been proposed for CILK1. [review]	31506943
2020-01-04 11:31:00	Study demonstrates that human ICK (intestinal cell kinase) that authors herein call CAPK (ciliopathy-associated protein kinase) interacts with human KIF3A and phosphorylates a conserved site Thr672 both in vitro and in vivo. Long, unstructured, non-catalytic carboxyl-terminal domain (CTD) of CAPK is required for this interaction with and phosphorylation of KIF3A.	31277411
2018-03-24 10:35:00	Our data provide evidence that heterozygous variants in ICK caused juvenile myoclonic epilepsy in 7% of the patients included in our analysis. Variant ICK affects cell processes that help explain microdysgenesis and polyspike networks observed on EEG in juvenile myoclonic epilepsy.	29539279

名称对应

Type	IDs
Synonymous	ECO, EJM10, LCK2, MRK
Gene	UniProtKB-ID: CILK1_HUMAN, A0A024RD59_HUMAN, B3KQG4_HUMAN UniprotKB: Q9UPZ9, A0A024RD59, B3KQG4 UniParc: UPI0000073DE8, UPI0000074253, UPI000015D961 EMBL: AB023153, BC136420, AL031178, BC152464, AK074892, BC035807, BC136421, AL162581, AF152469, CH471081, AF225919 Ensembl: ENSG00000112144 KO: hsa:22858
Nucleutide sequences	EMBL-CDS: AAG43364.1, AAH35807.1, EAX04400.1, AAI36421.1, BAA76780.2, AAI36422.1, AAF37278.1, AAI52465.1, EAX04404.1, EAX04403.1, EAX04402.1, BAG52026.1 Gene_ORFName: hCG_20817 Ensembl_TRS: ENST00000356971, ENST00000350082
Protein sequencees	Ensembl_PRO: ENSP00000349458, ENSP00000263043 RefSeq: NP_001362326.1, XP_011512723.1, NP_001362330.1, NP_001362329.1, NP_055735.1, XP_016865976.1, XP_011512722.1, NP_001362327.1, XP_016865974.1, NP_001362331.1, NP_001362328.1, XP_016865975.1, NP_057597.2
Others	UniRef100: UniRef100_B3KQG4, UniRef100_Q9UPZ9 UniRef90: UniRef90_Q9UPZ9 UniRef50: UniRef50_Q9UPZ9 UniGene: Hs.417022 CCDS: CCDS4949.1

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mRNA

Protein

UniprotKB

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Pubmed编号	文献信息	发表日期	相关基因
32732286	Anterograde trafficking of ciliary MAP kinase-like ICK/CILK1 by the intraflagellar transport machinery is required for intraciliary retrograde protein trafficking. J Biol Chem Kentaro Nakamura , Tatsuro Noguchi , Mariko Takahara , Yoshihiro Omori , Takahisa Furukawa , Yohei Katoh , Kazuhisa Nakayama	2020-09-18	-
32178256	Functional Alterations in Ciliogenesis-Associated Kinase 1 (CILK1) that Result from Mutations Linked to Juvenile Myoclonic Epilepsy. Cells Eric J Wang , Casey D Gailey , David L Brautigan , Zheng Fu	2020-03-12	-
31506943	Ciliogenesis associated kinase 1: targets and functions in various organ systems. FEBS Lett Zheng Fu , Casey D Gailey , Eric J Wang , David L Brautigan	2019-11-01	-
31277411	Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis. Cells Yoon Seon Oh , Eric J Wang , Casey D Gailey , David L Brautigan , Benjamin L Allen , Zheng Fu	2019-07-04	-
30021884	Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Mol Cell Proteomics Domenico Fasci , Hugo van Ingen , Richard A Scheltema , Albert J R Heck	2018-10-01	-
29845934	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Elife Tyler B Faust , Yang Li , Curtis W Bacon , Gwendolyn M Jang , Amit Weiss , Bhargavi Jayaraman , Billy W Newton , Nevan J Krogan , IvÃ¡n D'Orso , Alan D Frankel	2018-05-30	-
29539279	Variant Intestinal-Cell Kinase in Juvenile Myoclonic Epilepsy. N. Engl. J. Med. Julia N Bailey , Laurence de Nijs , Dongsheng Bai , Toshimitsu Suzuki , Hiroyuki Miyamoto , Miyabi Tanaka , Christopher Patterson , Yu-Chen Lin , Marco T Medina , MarÃa E Alonso , JosÃ© M Serratosa , Reyna M DurÃ³n , Viet H Nguyen , Jenny E Wight , Iris E MartÃnez-JuÃ¡rez , Adriana Ochoa , Aurelio Jara-Prado , Laura Guilhoto , Yolly Molina , Elsa M Yacubian , Minerva LÃ³pez-Ruiz , Yushi Inoue , Sunao Kaneko , Shinichi Hirose , Makiko Osawa , Hirokazu Oguni , Shinji Fujimoto , Thierry M Grisar , John M Stern , Kazuhiro Yamakawa , Bernard Lakaye , Antonio V Delgado-Escueta	2018-03-15	-
28718761	The human cytoplasmic dynein interactome reveals novel activators of motility. Elife William B Redwine , Morgan E DeSantis , Ian Hollyer , Zaw Min Htet , Phuoc Tien Tran , Selene K Swanson , Laurence Florens , Michael P Washburn , Samara L Reck-Peterson	2017-07-18	-
28611215	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Proc. Natl. Acad. Sci. U.S.A. Teng Fei , Yiwen Chen , Tengfei Xiao , Wei Li , Laura Cato , Peng Zhang , Maura B Cotter , Michaela Bowden , Rosina T Lis , Shuang G Zhao , Qiu Wu , Felix Y Feng , Massimo Loda , Housheng Hansen He , X Shirley Liu , Myles Brown	2017-06-27	-
28514442	Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper	2017-05-25	-

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