| Type | Description |
|---|---|
| Definition | sortilin related receptor 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-25 10:37:00 | SORL1 encodes SorLA, a key protein involved in the processing of the amyloid-beta (Abeta) precursor protein (APP) and the secretion of the Abeta peptide, the aggregation of which triggers AD pathophysiology. The association of SORL1 common and rare variants with AD risk is reviewed. A meta-analysis of published data on SORL1 rare variants in five large sequencing studies was performed. Review. | 30911827 |
| 2020-06-06 12:45:00 | higher serum level associated with adverse clinical outcomes in coronary artery disease | 32350212 |
| 2020-06-06 10:24:00 | LDLR, APOB, and ABCA1 mutations have been most frequently reported in familial hypercholesterolemia patients in the Middle East and North Africa region. (Review) | 30694837 |
| 2020-02-15 13:01:00 | The sLR11 increases during pregnancy, with levels further exaggerated in pre-eclampsia, and may be related to the pathology of pre-eclampsia. | 31299181 |
| 2019-09-14 12:43:00 | Data describe a transcript that encodes a truncated sorLA receptor, suggesting novel neuronal functions for sorLA and that alternative transcription provides a mechanism for SORL1 activity regulation. | 30078640 |
| Type | IDs |
|---|---|
| Synonymous | C11orf32, LR11, LRP9, SORLA, SorLA-1, gp250 |
| Gene |
UniProtKB-ID:
SORL_HUMAN,
A0A024R3H2_HUMAN
UniprotKB:
Q92673,
A0A024R3H2
UniParc:
UPI0000049047,
UPI000013D0B1
EMBL:
U60975,
AP000664,
Y08110,
BC137171,
CH471065,
AP000977
Ensembl:
ENSG00000137642
KO:
hsa:6653
|
| Nucleutide sequences |
EMBL-CDS:
EAW67525.1,
AAC50891.2,
CAA69325.1,
AAI37172.1,
EAW67526.1,
EAW67527.1
Gene_ORFName:
hCG_14958
Ensembl_TRS:
ENST00000260197
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000260197
RefSeq:
NP_003096.2
|
| Others |
UniRef100:
UniRef100_Q92673,
UniRef100_A0A024R3H2
UniRef90:
UniRef90_Q92673
UniRef50:
UniRef50_Q92673
UniGene:
Hs.368592
CCDS:
CCDS8436.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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