| Type | Description |
|---|---|
| Definition | MAP kinase interacting serine/threonine kinase 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:28:00 | Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis. | 32170339 |
| 2019-07-20 12:17:00 | Induction of Mnk2a by splice switching oligonucleotides in glioblastoma cells activated the p38-MAPK pathway, inhibited the oncogenic properties of the cells, re-sensitized the cells to chemotherapy and inhibited glioblastoma development in vivo | 30329087 |
| 2019-05-25 11:44:00 | We conclude that MNK2 overexpression in NSCLC is associated with proliferation, migration, invasion, and lower survival rates in patients via the phosphorylated eIF4E-mediated signaling pathway. | 28878291 |
| 2017-07-15 11:40:00 | Data show that galeterone (gal) and VNPT55 inhibit migration and invasion of prostate cancer cells, possibly by down-regulating protein expression via antagonizing the Mnk1/2-eIF4E axis. | 27618366 |
| 2016-07-16 10:06:00 | Data suggest MNK1/MNK2 stimulate mRNA translation but only of mRNA containing both 5-prime-terminal cap and hairpin duplex; this stimulation involves up-regulation of phosphorylation/mRNA un-winding activity of eIF4E (via decreased binding to eIF4G). | 26668315 |
| Type | IDs |
|---|---|
| Synonymous | GPRK7, MNK2 |
| Gene |
UniProtKB-ID:
MKNK2_HUMAN,
B3KS07_HUMAN
UniprotKB:
Q9HBH9,
B3KS07
UniParc:
UPI000178DFBE,
UPI000006E9B4,
UPI0000071DC5
EMBL:
BC073140,
AF237775,
AK092536,
AF237776,
AF125532
Ensembl:
ENSG00000099875
KO:
hsa:2872
|
| Nucleutide sequences |
EMBL-CDS:
AAG26337.1,
AAH73140.1,
AAG26336.1,
AAF17226.1,
BAG52569.1
Ensembl_TRS:
ENST00000309340,
ENST00000250896,
ENST00000591601
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000309485,
ENSP00000250896,
ENSP00000467811
RefSeq:
XP_024307239.1,
NP_951009.1,
NP_060042.2
|
| Others |
UniRef100:
UniRef100_Q9HBH9,
UniRef100_B3KS07
UniRef90:
UniRef90_Q9HBH9,
UniRef90_A0A2K5QD35
UniRef50:
UniRef50_Q9HBH9
UniGene:
Hs.515032
CCDS:
CCDS12080.1,
CCDS12079.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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