| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase-activated protein kinase 5 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 11:32:00 | Study identified the serine/threonine kinase MK5 as a positive regulator of YAP. MK5 physically interacted with YAP and counteracted CK1delta/epsilon-mediated YAP ubiquitination and degradation independent of LATS1/2. MK5 upregulation was associated with high levels of YAP expression and poor prognosis in clinical tumor samples, confirming its important role for YAP activity in human cancer. | 31578200 |
| 2018-06-02 11:12:00 | MK5 is being discussed as a putative novel regulator of cardiac fibroblast function. (Review) | 28941148 |
| 2016-11-12 10:51:00 | PRAK might be a potential therapeutic target of Alzheimer's disease involved in receptor for advanced glycation end products-mediated cell signaling induced by Abeta | 26758977 |
| 2016-03-05 11:04:00 | Plasma protein was found to positively associate with the 10-year change in paired associates learning assessment in asymptomatic older twins. | 26080319 |
| 2015-06-20 12:07:00 | Data highlight that DJ-1 is the downstream interacting target for PRAK, and in response to oxidative stress PRAK may exert a cytoprotective effect by facilitating DJ-1 to sequester Daxx in the nucleus, thus preventing cell death. | 25383140 |
| Type | IDs |
|---|---|
| Synonymous | MAPKAP-K5, MK-5, MK5, PRAK |
| Gene |
UniProtKB-ID:
MAPK5_HUMAN
UniprotKB:
Q8IW41
UniParc:
UPI0000074563,
UPI0000161429
EMBL:
AK122767,
CH471054,
AL110301,
BC041049,
BC000833,
AF032437,
BC047284
Ensembl:
ENSG00000089022
KO:
hsa:8550
|
| Nucleutide sequences |
EMBL-CDS:
CAB53747.1,
AAH41049.1,
AAC39863.1,
BAG53717.1,
EAW97981.1,
AAH47284.2,
AAH00833.1
Ensembl_TRS:
ENST00000550735,
ENST00000551404
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000449667,
ENSP00000449381
RefSeq:
NP_001358415.1,
NP_001358409.1,
NP_001358412.1,
NP_001358410.1,
NP_001358408.1,
NP_003659.2,
NP_001358414.1,
NP_001358416.1,
NP_001358413.1,
NP_620777.1,
NP_001358411.1
|
| Others |
UniRef100:
UniRef100_Q8IW41
UniRef90:
UniRef90_Q8IW41
UniRef50:
UniRef50_Q8IW41
UniGene:
Hs.333120,
Hs.413901
CCDS:
CCDS44976.1,
CCDS44975.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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