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9821 RB1CC1

9821

RB1CC1

RB1 inducible coiled-coil 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition RB1 inducible coiled-coil 1

研究结论

Date Results Publications
2021-04-17 13:13:00 Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy. 33226137
2021-03-20 13:31:00 ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer. 32516362
2021-02-13 13:28:00 The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment. 32773036
2019-10-19 12:19:00 the recruitment of the FIP200 CTR slows the phase separation of ubiquitinated proteins by p62 in a reconstituted system. Our data provide the molecular basis for a crosstalk between cargo condensation and autophagosome formation. 30853400
2019-10-19 10:23:00 we show that, essential for anti-bacterial autophagy, the cargo receptor NDP52 forms a trimeric complex with FIP200 and SINTBAD/NAP1, which are subunits of the autophagy-initiating ULK and the TBK1 kinase complex, respectively. FIP200 and SINTBAD/NAP1 are each recruited independently to bacteria via NDP52, as revealed by selective point mutations in their respective binding sites 30853402

名称对应

Type IDs
Synonymous ATG17, CC1, FIP200, PPP1R131
Gene
UniProtKB-ID: RBCC1_HUMAN
UniprotKB: Q8TDY2
UniParc: UPI00002106A1, UPI0000DBEF23
EMBL: BC017556, AC090814, D86958, AB059622, AY173931, AC113139
Ensembl: ENSG00000023287
KO: hsa:9821
Nucleutide sequences
EMBL-CDS: BAB69690.1, AAO17545.1, AAH17556.1, BAA13194.2
Ensembl_TRS: ENST00000435644, ENST00000025008
Protein sequencees
Ensembl_PRO: ENSP00000396067, ENSP00000025008
RefSeq: XP_016869598.1, XP_016869599.1, XP_016869594.1, XP_011515947.1, XP_011515946.1, XP_016869595.1, XP_016869593.1, XP_011515948.1, XP_016869592.1, XP_016869596.1, NP_001077086.1, XP_016869600.1, XP_011515945.1, XP_011515951.1, XP_016869601.1, XP_011515949.1, NP_055596.3, XP_016869597.1
Others
UniRef100: UniRef100_Q8TDY2
UniRef90: UniRef90_Q8TDY2
UniRef50: UniRef50_Q8TDY2
UniGene: Hs.196102
CCDS: CCDS47856.1, CCDS34892.1

全选

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