| Type | Description |
|---|---|
| Definition | transcriptional repressor GATA binding 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 12:52:00 | TRPS1 expression was found in all Intervertebral disc (IVD) of patients with IVD degeneration. TRPS1 expression levels significantly decreased with increasing grade of disc degeneration. Highly degenerated discs expressed low levels of TRPS1. Additionally, TRPS1 was able to repress miR-221 expression by associating with its promoter and miR-221 negatively control TRPS1 expression by targeting the TRPS1-3'UTR gene. | 31569377 |
| 2020-02-08 10:30:00 | Symptomes of four cases of Trichorhinophalangeal syndrome (TRPS) (three sporadic and one familial) were presented. | 31343132 |
| 2019-12-14 11:05:00 | TRPS1 is associated with the NuRD repressor complex. | 30380416 |
| 2019-09-07 11:43:00 | Results show that Trps1 regulates multidrug sensitivity of lung cancer cells. Also, Trps1 induces MGMT transcription through binding to its promoter region. These data indicate that multidrug resistance of lung cancer cells is partly associated with Trps1-regulated MGMT gene transcription. | 29601666 |
| 2019-05-25 12:28:00 | Study provide a novel mechanistic insight into the growth-regulatory role of TRPS1-USP4-HDAC2 axis by providing evidence that TRPS1 recruits USP4 to deubiquitinate and stabilize HDAC2. This is the first example of the non-transcription factor function of GATA transcription factor which affects the ubiquitination and transcription repressive function of HDAC2, acetylation of H4K16, and the deubiquitinase function of USP4. | 30071870 |
| Type | IDs |
|---|---|
| Synonymous | GC79, LGCR |
| Gene |
UniProtKB-ID:
TRPS1_HUMAN
UniprotKB:
Q9UHF7
UniParc:
UPI0000137646,
UPI0001A61554,
UPI00002104B8
EMBL:
AK000948,
BC125020,
AF183810,
AK304046,
AF178030,
AF264784
Ensembl:
ENSG00000104447
KO:
hsa:7227
|
| Nucleutide sequences |
EMBL-CDS:
AAI25021.1,
BAG64957.1,
BAA91441.1,
AAF23614.1,
AAG21134.1
Ensembl_TRS:
ENST00000640765,
ENST00000520276,
ENST00000395715,
ENST00000220888
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000220888,
ENSP00000379065,
ENSP00000492037,
ENSP00000428680
RefSeq:
NP_001269832.1,
NP_001317528.1,
NP_001269831.1,
NP_054831.2
|
| Others |
UniRef100:
UniRef100_Q9UHF7
UniRef90:
UniRef90_Q9UHF7
UniRef50:
UniRef50_Q9UHF7
UniGene:
Hs.657018
CCDS:
CCDS6318.2,
CCDS64957.1,
CCDS83316.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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