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5934 RBL2

5934

RBL2

RB transcriptional corepressor like 2

protein-coding

Homo sapiens

基因描述

Type Description
Definition RB transcriptional corepressor like 2

研究结论

Date Results Publications
2019-07-20 11:39:00 A point mutation in LxCxE motif of KDM5A/RBP2 renders it incapable of 130 kDa retinoblastoma-associated protein (p130)-interaction and hence, repression of E2F transcription factor 4 and (E2F)-regulated gene promoters. 29059406
2019-03-09 12:30:00 HSP27 promotes cell cycle progression of MRC-5 cells by suppressing expression of the transcriptional repressors E2F-4 and p130 30166342
2019-03-09 10:21:00 RBL2/p130 and AKT1 physically interact and AKT phosphorylates RBL2/p130 Ser941, located in the pocket domain, but not when this residue is mutated into Alanine. 29606701
2018-07-21 11:47:00 Three fold reduced Rbl2/p130 expression in these tumor tissues were noticed compared to their control tissues. DNA obtained from MNAse digested chromatin was used as PCR template. 29417345
2017-06-24 10:59:00 UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins 28289097

名称对应

Type IDs
Synonymous P130, Rb2
Gene
UniProtKB-ID: RBL2_HUMAN
UniprotKB: Q08999
UniParc: UPI000013D264, UPI00019154CB
EMBL: X74594, AC007342, U53220, X76061, BC034490, AK304283, S67171
Ensembl: ENSG00000103479
KO: hsa:5934
Nucleutide sequences
EMBL-CDS: CAA52671.1, AAH34490.1, BAH14149.1, AAC50479.1, AAB29227.1, CAA53661.1
Ensembl_TRS: ENST00000262133
Protein sequencees
Ensembl_PRO: ENSP00000262133
RefSeq: NP_005602.3, NP_001310540.1, NP_001310539.1, NP_001310538.1, NP_001310537.1, XP_016879002.1, XP_011521555.1
Others
UniRef100: UniRef100_Q08999
UniRef90: UniRef90_Q08999
UniRef50: UniRef50_Q08999
UniGene: Hs.513609
CCDS: CCDS10748.1

全选

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研究热度

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