| Type | Description |
|---|---|
| Definition | deoxyhypusine synthase |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:30:00 | Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase. | 32235505 |
| 2020-06-27 10:57:00 | DHPS-dependent hypusination of eIF5A1/2 is necessary for TGFbeta/fibronectin-induced breast cancer metastasis and associates with prognostically unfavorable genomic alterations in TP53 | 31558321 |
| 2019-11-23 12:42:00 | data suggest that rare biallelic variants in DHPS result in reduced enzyme activity that limits the hypusination of eIF5A and are associated with a neurodevelopmental disorder | 30661771 |
| 2017-09-02 12:09:00 | the use of N1-Guanyl-1,7-diaminoheptane, a DHPS inhibitor, resulted in a significant decrease in tumor formation in vivo. In patients with esophageal squamous cell carcinoma (ESCC), overexpression of DHPS in ESCC tumors was significantly associated with worse recurrence-free survival, and correlated with distant metastasis. | 27041563 |
| 2015-11-14 10:46:00 | Whereas, dhps mutation study revealed that triple mutant haplotype AGEAA (S436A+A437G+K540E) associated with Sulphadoxine resistance was found among 26% of P. falciparum field isolates. | 25511211 |
| Type | IDs |
|---|---|
| Synonymous | DHS, DS, MIG13 |
| Gene |
UniProtKB-ID:
DHYS_HUMAN,
A0A024R7D0_HUMAN,
A0A024R7E9_HUMAN
UniprotKB:
P49366,
A0A024R7D0,
A0A024R7E9
UniParc:
UPI0000D4DE46,
UPI00001293B4,
UPI000002A7E6
EMBL:
AJ001704,
AC010422,
AK291553,
BC014016,
AJ001703,
AJ001702,
U32178,
AJ001701,
U40579,
L39068,
U26266,
U79262,
AL520040,
BC000333,
CH471106
Ensembl:
ENSG00000095059
KO:
hsa:1725
|
| Nucleutide sequences |
EMBL-CDS:
AAH00333.1,
AAA96151.1,
AAB02175.1,
AAA86282.1,
AAB02179.1,
EAW84288.1,
AAB50208.1,
CAA04940.1,
AAH14016.1,
BAF84242.1,
EAW84293.1,
EAW84290.1,
EAW84292.1
Gene_ORFName:
hCG_73094,
hCG_73094
Ensembl_TRS:
ENST00000210060,
ENST00000351660,
ENST00000594424
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000471886,
ENSP00000210060,
ENSP00000221303
RefSeq:
NP_001356621.1,
NP_001193903.1,
NP_001356622.1,
NP_001356620.1,
NP_001921.1,
NP_037538.1
|
| Others |
UniRef100:
UniRef100_A0A024R7E9,
UniRef100_P49366
UniRef90:
UniRef90_P49366,
UniRef90_Q6EWQ6
UniRef50:
UniRef50_Q6EWQ6,
UniRef50_P49366
UniGene:
Hs.79064
CCDS:
CCDS12276.1,
CCDS59354.1,
CCDS12277.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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