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8575 PRKRA

8575

PRKRA

protein activator of interferon induced protein kinase EIF2AK2

protein-coding

Homo sapiens

基因描述

Type Description
Definition protein activator of interferon induced protein kinase EIF2AK2

研究结论

Date Results Publications
2020-09-12 15:58:00 A truncated PACT protein resulting from a frameshift mutation reported in movement disorder DYT16 triggers caspase activation and apoptosis. 31246344
2020-08-15 19:04:00 LGP2 binds to PACT to regulate RIG-I- and MDA5-mediated antiviral responses. 31575732
2020-03-21 10:53:00 acts as a negative regulator of PACT at multiple levels 31135270
2019-11-30 10:15:00 Study demonstrated that PACT is frequently overexpressed in mucinous ovarian cancer (MOC) cells and regulates oxaliplatin resistance of MOC cells. 30305341
2019-04-20 10:59:00 This study report the PRKRA mutation causing adulthood-onset dystonia. 29279192

名称对应

Type IDs
Synonymous DYT16, HSD14, PACT, RAX
Gene
UniProtKB-ID: PRKRA_HUMAN, B4DJC7_HUMAN
UniprotKB: O75569, B4DJC7
UniParc: UPI0000073B07, UPI000006D9A3, UPI0000D4EC43, UPI0000351183
EMBL: BC009470, CH471058, AK223107, AK296019, AY251164, BT007243, AL136615, CR533525, AF072860, AC009948, AK290601, AL833867, AF083033
Ensembl: ENSG00000180228
KO: hsa:8575
Nucleutide sequences
EMBL-CDS: AAP20061.1, BAF83290.1, CAD38725.1, AAD33099.1, AAP35907.1, EAX11036.1, AAX88882.1, AAC25672.1, CAG38556.1, BAD96827.1, CAB66550.1, AAH09470.1, BAG58789.1
Gene_ORFName: HSD14, HSD-14
Ensembl_TRS: ENST00000432031, ENST00000325748, ENST00000487082
Protein sequencees
Ensembl_PRO: ENSP00000318176, ENSP00000430604, ENSP00000393883
RefSeq: NP_001303291.1, NP_003681.1, XP_016860648.1, NP_001132990.1, XP_011510365.1, NP_001132989.1, XP_011510368.1
Others
UniRef100: UniRef100_A0A2J8VRE2, UniRef100_O75569
UniRef90: UniRef90_O75569
UniRef50: UniRef50_O75569
UniGene: Hs.570274
CCDS: CCDS2279.1, CCDS46461.1, CCDS46460.1

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