| Type | Description |
|---|---|
| Definition | BAI1 associated protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-14 12:06:00 | Phosphorylation-dependent inhibition of IRSp53 by 14-3-3 counters activation by Cdc42 and cytoskeletal effectors, resulting in down-regulation of filopodia dynamics and cancer cell migration. In serum-starved cells, increased IRSp53 phosphorylation triggers 14-3-3 binding, which inhibits filopodia formation and dynamics, irrespective of whether IRSp53 is activated by Cdc42 or downstream effectors (Eps8, Ena/VASP). | 30893014 |
| 2019-04-20 12:22:00 | IRSp53 heterodimer with only one subunit is phosphorylated, and each subunit of IRSp53 independently binds one 14-3-3 dimer. | 30696821 |
| 2018-12-22 10:19:00 | Coincident with the loss of PICK1 by GBF1-activated ARF1, CDC42 recruitment leads to the activation of IRSp53 and the complex, resulting in a burst of F-actin polymerisation potentially powering scission. | 29743604 |
| 2018-05-05 11:30:00 | A BAIAP2 polymorphism, rs8079626, affects medial frontal gyrus and inferior parietal lobe connectivity in attention deficit hyperactivity order adults. | 28938222 |
| 2017-11-18 12:16:00 | BAIAP2 is a candidate gene for mediating dendritic spine density abnormalities in schizophrenia. Data suggest that altered DNA methylation in schizophrenia may be a mechanism for schizophrenia-related dendritic spine density reductions. | 28195572 |
| Type | IDs |
|---|---|
| Synonymous | BAP2, FLAF3, IRSP53 |
| Gene |
UniProtKB-ID:
BAIP2_HUMAN,
I3L4C2_HUMAN
UniprotKB:
Q9UQB8,
I3L4C2
UniParc:
UPI000000D762,
UPI000000D763,
UPI000000D765,
UPI000006D90B,
UPI000000D764,
UPI0000074160,
UPI000006F124
EMBL:
AB017119,
BC014020,
AB017120,
AC115099,
U70669,
AK222670,
AB104726,
AC127496,
BC032559,
KC877672,
AB015019,
AB015020
Ensembl:
ENSG00000175866
KO:
hsa:10458
|
| Nucleutide sequences |
EMBL-CDS:
BAC57947.1,
BAD96390.1,
BAC57945.1,
BAA74773.1,
BAA36587.1,
BAC57948.1,
BAA36586.1,
BAA74774.1,
AAB93497.1,
AAH14020.1,
BAC57946.1,
AAH32559.1
Ensembl_TRS:
ENST00000435091,
ENST00000321300,
ENST00000321280,
ENST00000428708,
ENST00000575712,
ENST00000575245
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000458964,
ENSP00000401022,
ENSP00000315685,
ENSP00000413069,
ENSP00000316338,
ENSP00000461144
RefSeq:
XP_024306302.1,
NP_001372082.1,
XP_016879508.1,
NP_001372073.1,
NP_001372076.1,
NP_001372057.1,
NP_001372064.1,
NP_001372070.1,
NP_001372075.1,
XP_011522496.1,
NP_001372084.1,
NP_001372081.1,
NP_001372085.1,
NP_001372079.1,
NP_001372058.1,
NP_006331.1,
NP_001138360.1,
NP_001372056.1,
NP_059344.1,
NP_001372068.1,
NP_001372069.1,
NP_001372061.1,
NP_001372078.1,
NP_001372074.1,
NP_001372062.1,
NP_001372065.1,
NP_001372059.1,
NP_001372067.1,
XP_011522497.1,
NP_001372060.1,
NP_001372088.1,
NP_059345.1,
NP_001372066.1,
XP_016879506.1,
NP_001372087.1,
NP_001372083.1,
NP_001372086.1,
NP_001372080.1,
XP_011522498.1,
XP_016879507.1,
NP_001372063.1,
XP_011522495.1,
NP_001372077.1,
XP_024306303.1
|
| Others |
UniRef100:
UniRef100_Q9UQB8,
UniRef100_I3L4C2
UniRef90:
UniRef90_Q9UQB8
UniRef50:
UniRef50_Q9UQB8
UniGene:
Hs.128316
CCDS:
CCDS45806.1,
CCDS11777.1,
CCDS11776.1,
CCDS11775.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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