| Type | Description |
|---|---|
| Definition | cleavage and polyadenylation specific factor 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-03-28 10:26:00 | MiR-4458 inhibits breast cancer cell growth, migration, and invasiveness by targeting CPSF4; results suggest that the miR-4458-CPSF4-COX-2-hTERT axis might serve as a potential target for the treatment of breast cancer patients | 30970220 |
| 2018-08-11 11:13:00 | The authors define the molecular architecture of the core human CPSF complex comprising CPSF160, WDR33, CPSF30 and Fip1 and identify specific domains involved in inter-subunit interactions. Together, these results shed light on the function of CPSF in mediating polyA signal-dependent RNA cleavage and polyadenylation. | 29274231 |
| 2017-08-19 12:04:00 | Residues F103 and M106 within the NS1-CPSF4 binding region are important for viral replication. | 28554059 |
| 2017-07-29 10:39:00 | Cleavage and polyadenylation specific factor 4 targets NF-kappaB/cyclooxygenase-2 signaling to promote the growth and survival of non-small cell lung carcinoma cells. | 27450326 |
| 2016-12-17 11:18:00 | These findings support a role for iron in some zinc-finger proteins. Using electrophoretic mobility shift assays and fluorescence anisotropy, we report that CPSF30 selectively recognizes the AU-rich hexamer (AAUAAA) sequence present in pre-mRNA, providing the first molecular-based evidence to our knowledge for CPSF30/RNA binding. | 27071088 |
| Type | IDs |
|---|---|
| Synonymous | CPSF30, NAR, NEB-1, NEB1 |
| Gene |
UniProtKB-ID:
CPSF4_HUMAN,
B7Z7B0_HUMAN
UniprotKB:
O95639,
B7Z7B0
UniParc:
UPI000018CED3,
UPI000006D230,
UPI0000072392,
UPI000191528A
EMBL:
CH471091,
EF191081,
AK301745,
BC003101,
AC073063,
BC050738,
U79569,
CR542161,
CH236956
Ensembl:
ENSG00000160917
KO:
hsa:10898
|
| Nucleutide sequences |
EMBL-CDS:
CAG46958.1,
ABN05292.1,
EAW76668.1,
AAH03101.1,
AAD00321.1,
AAH50738.1,
EAL23878.1,
EAW76667.1,
BAH13546.1
Ensembl_TRS:
ENST00000292476,
ENST00000436336,
ENST00000441580
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000395311,
ENSP00000292476,
ENSP00000402224
RefSeq:
XP_016867191.1,
XP_011514057.1,
NP_001305091.1,
XP_016867189.1,
XP_016867192.1,
NP_001075028.1,
XP_011514059.1,
NP_001305089.1,
XP_016867190.1,
NP_001305090.1,
NP_006684.1,
XP_011514058.1
|
| Others |
UniRef100:
UniRef100_O95639,
UniRef100_B7Z7B0
UniRef90:
UniRef90_O95639,
UniRef90_B7Z7B0
UniRef50:
UniRef50_O95639,
UniRef50_Q8BQZ5-3
UniGene:
Hs.489287
CCDS:
CCDS47652.1,
CCDS5664.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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