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7936 NELFE

7936

NELFE

negative elongation factor complex member E

protein-coding

Homo sapiens

基因描述

Type Description
Definition negative elongation factor complex member E

研究结论

Date Results Publications
2020-09-26 13:03:00 NELFE-Dependent MYC Signature Identifies a Unique Cancer Subtype in Hepatocellular Carcinoma. 30833661
2020-04-04 11:13:00 NELFE expression was increased in pancreatic cancer (PC) tissues compared with the paired normal tissues. NELFE expression was upregulated in PC cells when compared with normal pancreatic cells. Knockdown of NELFE inhibited the proliferation, invasion and migration of PC cells. NELFE activates the Wnt/betacatenin signaling pathway and epithelialtomesenchymal transition by decreasing the stabilization of NDRG2 mRNA in PC. 31638184
2018-09-08 10:53:00 define two mutually exclusive complexes CBC-NELF-E and CBC-ARS2-PHAX, which likely act in respectively earlier and later phases of transcription 29101316
2017-11-25 15:03:00 A positively charged face of NELF-AC is involved in RNA binding, whereas the opposite face of the NELF-AC subcomplex binds NELF-B. NELF-B is predicted to form a HEAT repeat fold, also binds RNA in vivo, and anchors the subunit NELF-E, which is confirmed to bind RNA in vivo. 27282391
2016-05-21 12:39:00 novel actions of BRD4 and of NELF-E in GR-controlled gene induction have been uncovered. 26504077

名称对应

Type IDs
Synonymous D6S45, NELF-E, RD, RDBP, RDP
Gene
UniProtKB-ID: NELFE_HUMAN, A0A1U9X830_HUMAN
UniprotKB: P18615, A0A1U9X830
UniParc: UPI00017A7F2B, UPI000000127D, UPI00017A85B2
EMBL: X16105, M32276, BC025235, M33230, M32275, CR388219, KY500479, BC050617, AL662849, CH471081, L03411, AL645922, AL049547, BX005143, AF019413, AK300717, M33231, CR753845, M32274, AK302652, CR759782, AL844853
Ensembl: ENSG00000206357, ENSG00000233801, ENSG00000206268, ENSG00000231044, ENSG00000204356, ENSG00000229363
KO: hsa:7936
Nucleutide sequences
EMBL-CDS: AAB67979.1, CAB89308.1, BAG63891.1, BAG62393.1, AAH25235.1, AAH50617.1, CAA34231.1, EAX03553.1, AAC37523.1, AAA36308.1, AQY76952.1
Ensembl_TRS: ENST00000448628, ENST00000383343, ENST00000375429, ENST00000375425, ENST00000457397, ENST00000383174, ENST00000444811, ENST00000429857
Protein sequencees
Ensembl_PRO: ENSP00000394879, ENSP00000372660, ENSP00000393005, ENSP00000364574, ENSP00000403623, ENSP00000388400, ENSP00000372834, ENSP00000364578
RefSeq: XP_016866788.1, XP_011513215.1, NP_002895.3, XP_006715268.1
Others
UniRef100: UniRef100_P18615
UniRef90: UniRef90_P18615
UniRef50: UniRef50_P18615
UniGene: Hs.423935
CCDS: CCDS4730.1

全选

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